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Infection and Immunity, February 2001, p. 1215-1220, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1215-1220.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Restoration of Mga Function to a Streptococcus pyogenes Strain (M Type 50) That Is Virulent in Mice

Brandi Limbago,dagger Kevin S. McIver,Dagger Vikram Penumalli,§ Brian Weinrick,|| and June R. Scott*

Department of Microbiology and Immunology, Emory University Health Sciences Center, Atlanta, Georgia 30322

Received 8 August 2000/Returned for modification 17 October 2000/Accepted 14 November 2000

The Mga protein in B514Sm, a Streptococcus pyogenes strain isolated as a mouse pathogen, contains amino acid substitutions at conserved sites that render the protein defective. Replacement of mga50 with the functional homolog mga4.1 restored full expression of Mga-regulated proteins. Restoration of Mga function did not affect fibrinogen binding, nor did it affect virulence in several mouse models of group A streptococcus infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, 3001 Rollins Res. Center, Emory University Health Sciences Center, Atlanta GA 30322. Phone: (404) 727-0402. Fax: (404) 727-8999. E-mail: scott{at}microbio.emory.edu.

dagger Present address: Division of Infectious Diseases, Department of Pediatrics, Children's Hospital and Regional Medical Center, Seattle, WA 98105.

Dagger Present address: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048.

§ Present address: Medical College of Georgia, School of Medicine, Augusta, GA 30912.

|| Present address: Sackler Institute of Graduate Biomedical Sciences, NYU School of Medicine, New York, NY 10016.

Infection and Immunity, February 2001, p. 1215-1220, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1215-1220.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Vahling, C. M., McIver, K. S. (2005). Identification of Residues Responsible for the Defective Virulence Gene Regulator Mga Produced by a Natural Mutant of Streptococcus pyogenes. J. Bacteriol. 187: 5955-5966 [Abstract] [Full Text]  
  • Biswas, I., Germon, P., McDade, K., Scott, J. R. (2001). Generation and Surface Localization of Intact M Protein in Streptococcus pyogenes Are Dependent on sagA. Infect. Immun. 69: 7029-7038 [Abstract] [Full Text]  


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