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Infection and Immunity, February 2001, p. 1221-1225, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1221-1225.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Susceptibilities of Cryptococcus neoformans Strains to Platelet Binding In Vivo and to the Fungicidal Activity of Thrombin-Induced Platelet Microbicidal Proteins In Vitro

S. Nail,1 R. Robert,1,* F. Dromer,2 A. Marot-Leblond,1 and J. M. Senet1

Groupe d'Etude des Interactions Hôte-Parasite, Laboratoire de Parasitologie-Mycologie, Faculté de Pharmacie, 49000 Angers,1 and Centre National de Référence des Mycoses Humaines et des Antifongiques, Unité de Mycologie, Institut Pasteur, 75725 Paris,2 France

Received 31 July 2000/Returned for modification 14 September 2000/Accepted 8 November 2000

In this study we investigated the interactions between capsular and acapsular strains of Cryptococcus neoformans and blood platelets. In vivo microscopic observation of blood samples from mice inoculated with C. neoformans yeast cells demonstrated that encapsulated and nonencapsulated yeast cells disappeared quickly from the bloodstream and that platelets were attached solely to yeast cells of the nonencapsulated strains. In vitro we observed that only the acapsular strains were susceptible to the fungicidal activity of thrombin-induced platelet microbicidal proteins.

* Corresponding author. Mailing address: Groupe d'Etude des Interactions Hôte-Parasite, Laboratoire de Parasitologie-Mycologie, Faculté de Pharmacie, 16 Blvd. Daviers, 49000 Angers, France. Phone: (33)-02-41-22-66-62. Fax: (33)-02-41-48-67-33. E-mail: raymond.robert{at}univ-angers.fr.

Infection and Immunity, February 2001, p. 1221-1225, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1221-1225.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Yeaman, M. R., Cheng, D., Desai, B., Kupferwasser, L. I., Xiong, Y.-Q., Gank, K. D., Edwards, J. E. Jr., Bayer, A. S. (2004). Susceptibility to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Increased Fluconazole Efficacy against Experimental Endocarditis Due to Candida albicans. Antimicrob. Agents Chemother. 48: 3051-3056 [Abstract] [Full Text]  
  • Ikeda, R., Sugita, T., Jacobson, E. S., Shinoda, T. (2002). Laccase and Melanization in Clinically Important Cryptococcus Species Other than Cryptococcusneoformans. J. Clin. Microbiol. 40: 1214-1218 [Abstract] [Full Text]  


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