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 Previous Article

Infection and Immunity, February 2001, p. 1226-1229, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1226-1229.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mice Lacking Interleukin-2 (IL-2)/IL-15 Receptor beta  Chain Are Susceptible to Infection with Avirulent Salmonella enterica subsp. enterica Serovar Choleraesuis but Mice Lacking IL-2 Are Resistant

Hitoshi Nishimura,1,* Mitsuhiko Tagaya,1 Hironaka Tsunobuchi,1 Haruhiko Suzuki,2 Izumi Nakashima,2 and Yasunobu Yoshikai1

Laboratory of Host Defense & Germfree Life, Research Institute for Disease Mechanism and Control,1 and Department of Immunology,2 Nagoya University School of Medicine, Nagoya, Japan

Received 7 August 2000/Returned for modification 26 September 2000/Accepted 16 November 2000

Interleukin-2 (IL-2)/IL-15 receptor beta  (IL-15Rbeta )-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rbeta -/- mice infected with Salmonella, suggesting that IL-2/IL-15Rbeta signaling is important for the generation of protective Th1 cells.

* Corresponding author. Mailing address: Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466-8550, Japan. Phone: 81. 52. 744. 2447. Fax: 81. 52. 744. 2449. E-mail: nishihit{at}med.nagoya-u.ac.jp.

Infection and Immunity, February 2001, p. 1226-1229, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1226-1229.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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