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Infection and Immunity, March 2001, p. 1876-1879, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1876-1879.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Experimental Model of Human Body Louse Infection Using Green Fluorescent Protein-Expressing Bartonella quintana

Pierre-Edouard Fournier,1 Michael F. Minnick,2 Hubert Lepidi,1,3 Eric Salvo,1 and Didier Raoult1,*

Unité des rickettsies, CNRS:UPRESA 6020,1 and Laboratoire d'Histologie,3 Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05, France, and Division of Biological Sciences, University of Montana, Missoula, Montana 59812-10022

Received 7 August 2000/Accepted 18 October 2000

A laboratory colony of human body lice was experimentally infected by feeding on rabbits made artificially bacteremic with a green fluorescent protein-expressing Bartonella quintana. B. quintana was detected in the gut and feces until death but not in the eggs. The life span of the lice was not modified. The rabbit model should provide valuable clues to the role of lice in the transmission of B. quintana.


* Corresponding author. Mailing address: Unité des Rickettsies, CNRS:UPRESA 6020, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 04-91-38-55-17. Fax: (33) 04-91-83-03-90. E-mail: Didier.Raoult{at}medecine.univ.mrs.fr.


Infection and Immunity, March 2001, p. 1876-1879, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1876-1879.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.



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