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Infection and Immunity, March 2001, p. 1883-1888, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1883-1888.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Interference between Host Resistance to Listeria monocytogenes Infection and Ovalbumin-Induced Allergic Responses in Mice

Daisuke Mizuki,1 Tomisato Miura,1,2 Sanae Sasaki,1 Mayuko Mizuki,1 Hiroo Madarame,3 and Akio Nakane1,*

Department of Bacteriology, School of Medicine,1 and School of Allied Medical Sciences,2 Hirosaki University, Hirosaki, and Veterinary Teaching Hospital, Azabu University, Sagamihara,3 Japan

Received 7 July 2000/Returned for modification 18 October 2000/Accepted 20 November 2000

Listeria monocytogenes promotes the induction of the T-helper 1 (Th1) cell response, while ovalbumin (OVA) induces a Th2 cell response and allergic reactions, such as airway hyperreactivity and immunoglobulin E (IgE) production. When mice were immunized with OVA on day 7 after L. monocytogenes infection, eosinophilia in bronchoalveolar lavage and the production of total IgE, OVA-specific IgE, interleukin-4 (IL-4), and IL-5 in the circulation were markedly suppressed. Cytokine responses, including IL-4, IL-5, IL-10, IL-13, and gamma interferon, to OVA were decreased in the spleen cell cultures obtained from OVA-immunized mice that had been infected with L. monocytogenes. Conversely, when OVA-immunized mice were infected with L. monocytogenes, conversion from the nonlethal infection to the lethal infection occurred. Host resistance to L. monocytogenes infection in OVA-immunized mice was enhanced by the administration of anti-IL-10 monoclonal antibody. The present study indicates that striking interference is observed between Th1-inducing L. monocytogenes infection and Th2-driven OVA-induced airway hyperreactivity.

* Corresponding author. Mailing address: Department of Bacteriology, School of Medicine, Hirosaki University, Zaifu-cho 5, Hirosaki, Aomori 036-8562, Japan. Phone: 81-172 39-5032. Fax: 81-172 39-5034. E-mail: a27k03n0{at}cc.hirosaki-u.ac.jp.

Infection and Immunity, March 2001, p. 1883-1888, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1883-1888.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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