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Infection and Immunity, March 2001, p. 1909-1913, Vol. 69, No. 3
Molecular Microbiology Group, Division of
Cell and Molecular Medicine, University of Southampton Medical School,
Southampton General Hospital, Southampton SO16 6YD, United Kingdom
Received 7 August 2000/Returned for modification 17 October
2000/Accepted 10 December 2000
The pathological features of ascending gonococcal infection suggest
that proinflammatory mediators secreted by tissue-resident macrophages
are important components of the host response. Challenge of fully
differentiated, mature macrophages with variants of Neisseria gonorrhoeae strain P9 or purified bacterial surface components (pili, lipooligosaccharide, and outer membrane vesicles) induced the
secretion of interleukin 6 (IL-6), tumor necrosis factor alpha, growth-related protein
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.3.1909-1913.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Interactions of Neisseria
gonorrhoeae with Mature Human Macrophage Opacity Proteins
Influence Production of Proinflammatory Cytokines
, macrophage inflammatory protein 1
(MIP-1
), and RANTES cytokines but had no effect on IL-8 production.
No secretion of IL-1
, epithelial-derived neutrophil attractant 78, granulocyte-macrophage colony-stimulating factor, IL-10, or IL-12 cytokines was observed. Notably, the P9-Opab protein, in
comparison to P9-Opaa, increased the association of
gonococci with macrophages and elevated the secretion of cytokines.
Thus, variation in Opa protein expression by the gonococcus may be a
determining factor in the severity of pelvic inflammatory disease.
*
Corresponding author. Mailing address: Molecular
Microbiology Group, Mailpoint 814, Division of Cell and Molecular
Medicine, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom. Phone: (44)
02380-796974. Fax: (44) 02380-796992. E-mail:
mc4{at}soton.ac.uk.
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