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Infection and Immunity, March 2001, p. 1914-1916, Vol. 69, No. 3
Neurobiologisches Labor, Neurologische und
Psychiatrische Klinik, 37075 Göttingen, Germany
Received 21 August 2000/Returned for modification 6 November
2000/Accepted 27 November 2000
Matrix metalloproteinases (MMPs) may contribute to an impaired
endothelial layer in several diseases. We examined the effect of
heat-inactivated Streptococcus pneumoniae R6 on MMP-2 and
MMP-9 release by cultured aortic and brain capillary endothelial cells. Treatment with heat-inactivated S. pneumoniae caused an
increased release of MMP-2 by both cell types.
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.3.1914-1916.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Regulation of Matrix Metalloproteinase Expression in Endothelial
Cells by Heat-Inactivated Streptococcus pneumoniae
*
Corresponding author. Mailing address:
Neurobiologisches Labor, Psychiatrische Klinik, von-Siebold-Straße 5, 37075 Göttingen, Germany. Phone: 49-551-396689/8363. Fax:
49-551-399337/8405. E-mail: umichel{at}gwdg.de.
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