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Infection and Immunity, March 2001, p. 1914-1916, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1914-1916.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Regulation of Matrix Metalloproteinase Expression in Endothelial Cells by Heat-Inactivated Streptococcus pneumoniae

Uwe Michel,* Rita Zobotke, Michael Mäder, and Roland Nau

Neurobiologisches Labor, Neurologische und Psychiatrische Klinik, 37075 Göttingen, Germany

Received 21 August 2000/Returned for modification 6 November 2000/Accepted 27 November 2000

Matrix metalloproteinases (MMPs) may contribute to an impaired endothelial layer in several diseases. We examined the effect of heat-inactivated Streptococcus pneumoniae R6 on MMP-2 and MMP-9 release by cultured aortic and brain capillary endothelial cells. Treatment with heat-inactivated S. pneumoniae caused an increased release of MMP-2 by both cell types.

* Corresponding author. Mailing address: Neurobiologisches Labor, Psychiatrische Klinik, von-Siebold-Straße 5, 37075 Göttingen, Germany. Phone: 49-551-396689/8363. Fax: 49-551-399337/8405. E-mail: umichel{at}gwdg.de.

Infection and Immunity, March 2001, p. 1914-1916, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1914-1916.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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