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Infection and Immunity, March 2001, p. 1924-1928, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1924-1928.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Expression of Hemin Receptor Molecule ChuA Is Influenced by RfaH in Uropathogenic Escherichia coli Strain 536

Gábor Nagy,1,2 Ulrich Dobrindt,1 Maren Kupfer,1 Levente Emödy,2 Helge Karch,3 and Jörg Hacker1,*

Institut für Molekulare Infektionsbiologie, Universität Würzburg, 97070 Würzburg,1 and Institut für Hygiene und Mikrobiologie, Universität Würzburg, 97080 Würzburg,3 Germany, and Institute of Medical Microbiology and Immunology, University of Pécs, 7624 Pécs, Hungary2

Received 8 September 2000/Returned for modification 20 October 2000/Accepted 4 December 2000

The outer membrane protein ChuA responsible for hemin utilization has been recently identified in several pathogenic Escherichia coli strains. We report that the regulatory protein RfaH influences ChuA expression in the uropathogenic E. coli strain 536. In an rfaH mutant, the chuA transcript as well as the ChuA protein levels were significantly decreased in comparison with those in the wild-type strain. Within the chuA gene, a consensus motif known as the JUMPStart (just upstream of many polysaccharide associated gene starts) sequence was found, which is shared by RfaH-affected operons. Furthermore, the presence of two different subclasses of the chuA determinant and their distribution in E. coli pathogroups are described.

* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Röntgenring 11, D-97070 Würzburg, Germany. Phone: 49 (0)931 312575. Fax: 49 (0)931 312578. E-mail: j.hacker{at}mail.uni-wuerzburg.de.

Infection and Immunity, March 2001, p. 1924-1928, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1924-1928.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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