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Infection and Immunity, April 2001, p. 2643-2649, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2643-2649.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Resolution of Secondary Chlamydia trachomatis Genital Tract Infection in Immune Mice with Depletion of Both CD4+ and CD8+ T cells

Sandra G. Morrison and Richard P. Morrison*

Department of Microbiology, Montana State University, Bozeman, Montana 59717

Received 6 November 2000/Returned for modification 28 December 2000/Accepted 17 January 2001

The essential role of T cells in the resolution of primary murine Chlamydia trachomatis genital tract infection is inarguable; however, much less is known about the mechanisms that confer resistance to reinfection. We previously established that CD4+ T cells and B cells contribute importantly to resistance to reinfection. In our current studies, we demonstrate that immune mice concurrently depleted of both CD4+ T cells and CD8+ T cells resisted reinfection as well as immunocompetent wild-type mice. The in vivo depletion of CD4+ and CD8+ T cells resulted in diminished chlamydia-specific delayed-type hypersensitivity responses, but antichlamydial antibody responses were unaffected. Our data indicate that immunity to chlamydial genital tract reinfection does not rely solely upon immune CD4+ or CD8+ T cells and further substantiate a predominant role for additional effector immune responses, such as B cells, in resistance to chlamydial genital tract reinfection.

* Corresponding author. Mailing address: Department of Microbiology, Lewis Hall Room 109, Montana State University, Bozeman, MT 59717. Phone: (406) 994-7959. Fax: (406) 994-4926. E-mail: morrison{at}montana.edu.

Infection and Immunity, April 2001, p. 2643-2649, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2643-2649.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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