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Infection and Immunity, April 2001, p. 2700-2707, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2700-2707.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Intracellular Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in Buccal Epithelial Cells Collected from Human Subjects

Joel D. Rudney,1,* Ruoqiong Chen,1 and Gerald J. Sedgewick2

Department of Oral Science and Minnesota Oral Health Clinical Research Center, School of Dentistry,1 and Biomedical Imaging and Processing Laboratory, Department of Neuroscience,2 University of Minnesota, Minneapolis, Minnesota 55455

Received 4 August 2000/Returned for modification 2 October 2000/Accepted 21 December 2000

The mouth may provide an accessible model for studying bacterial interactions with human cells in vivo. Using fluorescent in situ hybridization and laser scanning confocal microscopy, we found that human buccal epithelial cells from 23 of 24 subjects were infected with intracellular bacteria, including the periodontal pathogens Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, as well as other species which have yet to be identified. Buccal cell invasion may allow fastidious anaerobes to establish themselves in aerobic sites that otherwise present an unfavorable environment. Exfoliated buccal epithelial cells might provide a protected route for bacterial transmission between different oral sites within and between hosts.

* Corresponding author. Mailing address: Department of Oral Science, University of Minnesota, 17-252 Moos Tower, 515 Delaware St., S.E., Minneapolis, MN 55455. Phone: (612) 624-7199. Fax: (612) 626-2651. E-mail: jrudney{at}tc.umn.edu.

Infection and Immunity, April 2001, p. 2700-2707, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2700-2707.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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