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Infection and Immunity, April 2001, p. 2708-2713, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2708-2713.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antigastric Autoantibodies in Ferrets Naturally Infected with Helicobacter mustelae

Tadhg Ó Cróinín,1,2 Marguerite Clyne,1,2,* Ben J. Appelmelk,3 and Brendan Drumm1,2

The Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin,1 and Department of Pediatrics, The Conway Institute of Molecular and Biomedical Research, University College Dublin,2 Dublin, Ireland, and Department of Medical Microbiology, Vrije Universiteit, Amsterdam, The Netherlands3

Received 3 July 2000/Returned for modification 2 November 2000/Accepted 3 January 2001

Infection with Helicobacter pylori has been associated with induction of autoantibodies that cross-react with the gastric mucosa. There have been discordant reports as to whether or not these autoantibodies arise due to molecular mimicry between H. pylori and host cell antigens on parietal cells. In this study, we investigated whether molecular mimicry by H. mustelae causes autoantibodies in infected ferrets. Serum from H. mustelae-infected ferrets reacted with parietal cells in the ferret gastric mucosa but not with duodenal or colonic mucosa. These sera did not react with the blood group A epitope on erythrocytes or H. mustelae lipopolysaccharide, and absorption with H. mustelae whole cells or red blood cells did not remove autoantibodies. In conclusion, ferrets naturally infected with H. mustelae generate antibodies that react with parietal cells, but these autoantibodies are not due to molecular mimicry.

* Corresponding author. Mailing address: Department of Paediatrics, University College Dublin, The Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland. Phone: 00353-1-4556901. Fax: 00353-1-4555307. E-mail: marguerite.clyne{at}ucd.ie.

Infection and Immunity, April 2001, p. 2708-2713, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2708-2713.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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