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Infection and Immunity, April 2001, p. 2718-2722, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2718-2722.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Differential Gene Expression during Meningeal-Meningococcal Interaction: Evidence for Self-Defense and Early Release of Cytokines and Chemokines

Damien B. Wells,1 Patrick J. Tighe,2 Karl G. Wooldridge,1 Karen Robinson,1 and Dlawer A. A. Ala' Aldeen1,*

Molecular Bacteriology and Immunology Group, Divisions of Microbiology and Infectious Diseases1 and Immunology,2 University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom

Received 13 November 2000/Returned for modification 11 December 2000/Accepted 21 December 2000

Using microarray technology, we studied the early differential expression of 3,528 genes in human meningothelial cells in response to meningococcal challenge. Thirty-two genes were up-regulated, and four were down-regulated. Those up-regulated included the tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-8 (but not IL-1beta ) genes, suggesting that meningeal cells may be a local and early source of these cytokines. Also, a trend in up-regulation of anti-apoptotic genes and down-regulation of pro-apoptotic genes was observed. This is the first evidence that meningothelial cells may mount cytoprotective responses to pathogenic bacteria.

* Corresponding author. Mailing address: University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom. Phone: (44) 115 849 3321. Fax: (44) 115 970 9233. E-mail: daa{at}nottingham.ac.uk.

Infection and Immunity, April 2001, p. 2718-2722, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2718-2722.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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