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Infection and Immunity, April 2001, p. 2723-2727, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2723-2727.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Intracellular Crystal Formation as a Mechanism of Cytotoxicity in Murine Pulmonary Cryptococcus neoformans Infection

Marta Feldmesser,1,* Yvonne Kress,2 and Arturo Casadevall1,3

Division of Infectious Diseases, Department of Medicine,1 Department of Pathology,2 and Department of Microbiology and Immunology,3 Albert Einstein College of Medicine, Bronx, New York

Received 17 November 2000/Returned for modification 27 December 2000/Accepted 13 January 2001

Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.

* Corresponding author. Mailing address: Marta Feldmesser, Albert Einstein College of Medicine, Golding Building, Room 701, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-3730. Fax: (718) 430-8701. E-mail: feldmess{at}aecom.yu.edu.

Infection and Immunity, April 2001, p. 2723-2727, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2723-2727.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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