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Infection and Immunity, April 2001, p. 2728-2731, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2728-2731.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Protective Role of Lung Surfactant Protein D in a Murine Model of Invasive Pulmonary Aspergillosis

Taruna Madan,1 Uday Kishore,2,3 Mamta Singh,1,4 Peter Strong,2 Ejaj M. Hussain,4 Kenneth B. M. Reid,2,* and P. Usha Sarma1

Centre for Biochemical Technology, Council for Scientific and Industrial Research, Delhi 110007,1 and Department of Biosciences, Jamia Millia Central University, Delhi 110025,4 India, and Department of Biochemistry, Medical Research Council Immunochemistry Unit, University of Oxford, Oxford OX1 3QU,2 and Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS,3 United Kingdom

Received 5 September 2000/Returned for modification 10 October 2000/Accepted 21 December 2000

The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.

* Corresponding author. Mailing address: Department of Biochemistry, Medical Research Council Immunochemistry Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom. Phone: 44-1865-275353. Fax: 44-1865-275729. E-mail: kbmreid{at}bioch.ox.ac.uk.

Infection and Immunity, April 2001, p. 2728-2731, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2728-2731.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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