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Infection and Immunity, April 2001, p. 2736-2738, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2736-2738.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Induction of Cell-Associated Chemokines after Endotoxin Administration to Healthy Humans

Dariusz P. Olszyna,1,2 Evert De Jonge,3 Pascale E. P. Dekkers,1 Sander J. H. van Deventer,1 and Tom van der Poll1,2,*

Department of Experimental Internal Medicine,1 Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS,2 and Department of Intensive Care,3 Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 6 September 2000/Returned for modification 24 October 2000/Accepted 26 December 2000

Erythrocytes express the Duffy antigen receptor for chemokines. Endotoxin injection into humans induced high levels of interleukin-8 (IL-8), growth-related oncogene alpha , and monocyte chemoattractant protein 1 in circulating erythrocytes. IL-8 was also recovered from mononuclear and polymorphonuclear cells. Cell-associated chemokines may more accurately reflect their production than plasma concentrations.

* Corresponding author. Mailing address: Academic Medical Center, Room G2-132, Department of Experimental Internal Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5669111. Fax: 31-20-6977192. E-mail: t.vanderpoll{at}amc.uva.nl.

Infection and Immunity, April 2001, p. 2736-2738, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2736-2738.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Dessing, M. C., de Vos, A. F., Florquin, S., van der Poll, T. (2006). Monocyte Chemoattractant Protein 1 Does Not Contribute to Protective Immunity against Pneumococcal Pneumonia. Infect. Immun. 74: 7021-7023 [Abstract] [Full Text]  
  • Lee, J. S., Frevert, C. W., Wurfel, M. M., Peiper, S. C., Wong, V. A., Ballman, K. K., Ruzinski, J. T., Rhim, J. S., Martin, T. R., Goodman, R. B. (2003). Duffy Antigen Facilitates Movement of Chemokine Across the Endothelium In Vitro and Promotes Neutrophil Transmigration In Vitro and In Vivo. J. Immunol. 170: 5244-5251 [Abstract] [Full Text]  


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