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Infection and Immunity, April 2001, p. 2762-2765, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2762-2765.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficile Toxin A in Mice

Amir Qamar, Samer Aboudola, Michel Warny, Pierre Michetti, Charalabos Pothoulakis, J. Thomas LaMont, and Ciarán P. Kelly*

Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215

Received 26 October 2000/Returned for modification 13 December 2000/Accepted 16 January 2001

Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The administration of C. difficile toxoid A by gavage to S. boulardii-fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels (P = 0.003) and a 4.4-fold increase in specific intestinal anti-toxin A levels (P < 0.001). Enhancing host intestinal immune responses may be an important mechanism for S. boulardii-mediated protection against diarrheal illnesses.

* Corresponding author. Mailing address: Dana 601, Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215. Phone: (617) 667-1264. Fax: (617) 975-5071. E-mail: ciaran_kelly{at}caregroup.harvard.edu.

Infection and Immunity, April 2001, p. 2762-2765, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2762-2765.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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