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Infection and Immunity, April 2001, p. 2766-2771, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2766-2771.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

HLA-A*01-Restricted Cytotoxic T-Lymphocyte Epitope from the Plasmodium falciparum Circumsporozoite Protein

Anita Kumar,1,2,* Sanjai Kumar,1,3 Thong P. Le,1,4 Scott Southwood,5 John Sidney,5 Joe Cohen,6 Alessandro Sette,5 and Stephen L. Hoffman1

Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-75001; Henry M. Jackson Foundation, Rockville, Maryland 208522; Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 212053; Department of Medicine, St. Luke's Hospital, Bethlehem, Pennsylvania 180154; Epimmune Inc., San Diego, California 921215; and SmithKline Beecham Biologicals, Rixensart, Belgium6

Received 1 August 2000/Returned for modification 7 September 2000/Accepted 18 January 2001

Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians.

* Corresponding author. Mailing address: Malaria Program, Naval Medical Research Center, 503 Robert Grant Ave., RM3W13, Silver Spring, MD 20910-7500. Phone: (301) 319-7572. Fax: (301) 319-7545. E-mail: kumara{at}nmrc.navy.mil.

Infection and Immunity, April 2001, p. 2766-2771, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2766-2771.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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Copyright © 2001 by the American Society for Microbiology. All rights reserved.