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Infection and Immunity, May 2001, p. 2808-2814, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.2808-2814.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Role of Mannoprotein in Induction and Regulation of Immunity to Cryptococcus neoformans

Donatella Pietrella,1 Robert Cherniak,2 Carla Strappini,1 Stefano Perito,1 Paolo Mosci,1 Francesco Bistoni,1 and Anna Vecchiarelli1,*

Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy,1 and Department of Chemistry, Georgia State University, Atlanta, Georgia 303032

Received 2 October 2000/Returned for modification 11 November 2000/Accepted 31 January 2001

Our previous observations showed that mannoprotein (MP) induces early and massive production of interleukin-12 (IL-12) in vitro. This study was designed to investigate whether this phenomenon could be applied in vivo and to determine the biological significance of MP in Cryptococcus neoformans infection. The results reported here show that MP treatment induces IL-12 secretion by splenic macrophages and IL-12 p40 mRNA in the brain. During C. neoformans infection, MP reinforced IL-12 and IFN-gamma secretion that coincided with enhanced antifungal activity of natural effector cells, early resolution of the inflammatory process, and clearance of fungal load from the brain. These studies show that MP is a key inflammatory mediator that induces a protective immune response against C. neoformans infection. This information can be used to facilitate the design of a rational approach to manipulate the immune response to C. neoformans.

* Corresponding author. Mailing address: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. Phone: 39-075-585-7407. Fax: 39-075-585-7403. E-mail: vecchiar{at}unipg.it.

Infection and Immunity, May 2001, p. 2808-2814, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.2808-2814.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.