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Infection and Immunity, May 2001, p. 3264-3270, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3264-3270.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Immunological Basis for Reactivation of Tuberculosis in Mice

J. Turner,1,* M. Gonzalez-Juarrero,1 B. M. Saunders,1,dagger J. V. Brooks,1 P. Marietta,1 D. L. Ellis,1 A. A. Frank,2 A. M. Cooper,1 and I. M. Orme1

Departments of Microbiology1 and Pathology,2 Colorado State University, Fort Collins, Colorado 80523

Received 15 September 2000/Returned for modification 13 December 2000/Accepted 9 February 2001

In this study different inbred strains of mice appeared to control and contain a low dose aerosol infection with Mycobacterium tuberculosis in a similar manner, giving rise to a chronic state of disease. Thereafter, however, certain strains gradually began to show evidence of regrowth of the infection, whereas others consistently did not. Using C57BL/6 mice as an example of a resistant strain and CBA/J mice as an example of a strain susceptible to bacterial growth, we found that these animals revealed distinct differences in the cellular makeup of lung granulomas. The CBA/J mice exhibited a generally poor lymphocyte response within the lungs and vastly increased degenerative pathology at a time associated with regrowth of the infection. As a possible explanation for these events, it was then observed that the CBA/J mouse strain was also less able to upregulate adhesion molecules, including CD11a and CD54, on circulating lymphocytes. These results therefore suggest that a failure to control a chronic infection with M. tuberculosis may reflect an inability to localize antigen-specific lymphocytes within the lung.

* Corresponding author. Mailing address: Department of Microbiology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-6127. Fax: (970) 491-1815. E-mail: Jturner{at}cvmbs.colostate.edu.

dagger Present address: Centenary Institute, Newtown, NSW 2042, Australia.

Infection and Immunity, May 2001, p. 3264-3270, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3264-3270.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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