This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Turner, J.
Right arrow Articles by Orme, I. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Turner, J.
Right arrow Articles by Orme, I. M.

 Previous Article  |  Next Article 

Infection and Immunity, May 2001, p. 3264-3270, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3264-3270.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Immunological Basis for Reactivation of Tuberculosis in Mice

J. Turner,1,* M. Gonzalez-Juarrero,1 B. M. Saunders,1,dagger J. V. Brooks,1 P. Marietta,1 D. L. Ellis,1 A. A. Frank,2 A. M. Cooper,1 and I. M. Orme1

Departments of Microbiology1 and Pathology,2 Colorado State University, Fort Collins, Colorado 80523

Received 15 September 2000/Returned for modification 13 December 2000/Accepted 9 February 2001

In this study different inbred strains of mice appeared to control and contain a low dose aerosol infection with Mycobacterium tuberculosis in a similar manner, giving rise to a chronic state of disease. Thereafter, however, certain strains gradually began to show evidence of regrowth of the infection, whereas others consistently did not. Using C57BL/6 mice as an example of a resistant strain and CBA/J mice as an example of a strain susceptible to bacterial growth, we found that these animals revealed distinct differences in the cellular makeup of lung granulomas. The CBA/J mice exhibited a generally poor lymphocyte response within the lungs and vastly increased degenerative pathology at a time associated with regrowth of the infection. As a possible explanation for these events, it was then observed that the CBA/J mouse strain was also less able to upregulate adhesion molecules, including CD11a and CD54, on circulating lymphocytes. These results therefore suggest that a failure to control a chronic infection with M. tuberculosis may reflect an inability to localize antigen-specific lymphocytes within the lung.

* Corresponding author. Mailing address: Department of Microbiology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-6127. Fax: (970) 491-1815. E-mail: Jturner{at}cvmbs.colostate.edu.

dagger Present address: Centenary Institute, Newtown, NSW 2042, Australia.

Infection and Immunity, May 2001, p. 3264-3270, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3264-3270.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Beamer, G. L., Flaherty, D. K., Assogba, B. D., Stromberg, P., Gonzalez-Juarrero, M., de Waal Malefyt, R., Vesosky, B., Turner, J. (2008). Interleukin-10 Promotes Mycobacterium tuberculosis Disease Progression in CBA/J Mice. J. Immunol. 181: 5545-5550 [Abstract] [Full Text]  
  • Russell-Goldman, E., Xu, J., Wang, X., Chan, J., Tufariello, J. M. (2008). A Mycobacterium tuberculosis Rpf Double-Knockout Strain Exhibits Profound Defects in Reactivation from Chronic Tuberculosis and Innate Immunity Phenotypes. Infect. Immun. 76: 4269-4281 [Abstract] [Full Text]  
  • Beamer, G. L., Flaherty, D. K., Vesosky, B., Turner, J. (2008). Peripheral Blood Gamma Interferon Release Assays Predict Lung Responses and Mycobacterium tuberculosis Disease Outcome in Mice. CVI 15: 474-483 [Abstract] [Full Text]  
  • Taylor, J. L., Hattle, J. M., Dreitz, S. A., Troudt, J. M., Izzo, L. S., Basaraba, R. J., Orme, I. M., Matrisian, L. M., Izzo, A. A. (2006). Role for Matrix Metalloproteinase 9 in Granuloma Formation during Pulmonary Mycobacterium tuberculosis Infection. Infect. Immun. 74: 6135-6144 [Abstract] [Full Text]  
  • Kamath, A. B., Behar, S. M. (2005). Anamnestic Responses of Mice following Mycobacterium tuberculosis Infection. Infect. Immun. 73: 6110-6118 [Abstract] [Full Text]  
  • Aldwell, F. E., Brandt, L., Fitzpatrick, C., Orme, I. M. (2005). Mice Fed Lipid-Encapsulated Mycobacterium bovis BCG Are Protected against Aerosol Challenge with Mycobacterium tuberculosis. Infect. Immun. 73: 1903-1905 [Abstract] [Full Text]  
  • Kamath, A. B., Alt, J., Debbabi, H., Taylor, C., Behar, S. M. (2004). The Major Histocompatibility Complex Haplotype Affects T-Cell Recognition of Mycobacterial Antigens but Not Resistance to Mycobacterium tuberculosis in C3H Mice. Infect. Immun. 72: 6790-6798 [Abstract] [Full Text]  
  • Turner, J., Dobos, K. M., Keen, M. A, Frank, A. A., Ehlers, S., Orme, I. M., Belisle, J. T., Cooper, A. M. (2004). A Limited Antigen-Specific Cellular Response Is Sufficient for the Early Control of Mycobacterium tuberculosis in the Lung but Is Insufficient for Long-Term Survival. Infect. Immun. 72: 3759-3768 [Abstract] [Full Text]  
  • Cardona, P.-J., Gordillo, S., Diaz, J., Tapia, G., Amat, I., Pallares, A., Vilaplana, C., Ariza, A., Ausina, V. (2003). Widespread Bronchogenic Dissemination Makes DBA/2 Mice More Susceptible than C57BL/6 Mice to Experimental Aerosol Infection with Mycobacterium tuberculosis. Infect. Immun. 71: 5845-5854 [Abstract] [Full Text]  
  • Turner, O. C., Keefe, R. G., Sugawara, I., Yamada, H., Orme, I. M. (2003). SWR Mice Are Highly Susceptible to Pulmonary Infection with Mycobacterium tuberculosis. Infect. Immun. 71: 5266-5272 [Abstract] [Full Text]  
  • Turner, O. C., Basaraba, R. J., Orme, I. M. (2003). Immunopathogenesis of Pulmonary Granulomas in the Guinea Pig after Infection with Mycobacterium tuberculosis. Infect. Immun. 71: 864-871 [Abstract] [Full Text]  
  • Turner, J., Gonzalez-Juarrero, M., Ellis, D. L., Basaraba, R. J., Kipnis, A., Orme, I. M., Cooper, A. M. (2002). In Vivo IL-10 Production Reactivates Chronic Pulmonary Tuberculosis in C57BL/6 Mice. J. Immunol. 169: 6343-6351 [Abstract] [Full Text]  
  • Gruppo, V., Turner, O. C., Orme, I. M., Turner, J. (2002). Reduced up-regulation of memory and adhesion/integrin molecules in susceptible mice and poor expression of immunity to pulmonary tuberculosis. Microbiology 148: 2959-2966 [Abstract] [Full Text]  
  • Chackerian, A. A., Alt, J. M., Perera, T. V., Dascher, C. C., Behar, S. M. (2002). Dissemination of Mycobacterium tuberculosis Is Influenced by Host Factors and Precedes the Initiation of T-Cell Immunity. Infect. Immun. 70: 4501-4509 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»