This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hodder, A. N.
Right arrow Articles by Anders, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hodder, A. N.
Right arrow Articles by Anders, R. F.

 Previous Article  |  Next Article 

Infection and Immunity, May 2001, p. 3286-3294, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3286-3294.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Specificity of the Protective Antibody Response to Apical Membrane Antigen 1

Anthony N. Hodder,* Pauline E. Crewther, and Robin F. Anders

The Cooperative Research Center for Vaccine Technology and The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, 3052, Australia

Received 20 September 2000/Returned for modification 6 November 2000/Accepted 29 December 2000

Apical membrane antigen 1 (AMA1) is considered one of the leading candidates for inclusion in a vaccine against blood stages of Plasmodium falciparum. Although the ama1 gene is relatively conserved compared to those for some other potential vaccine components, numerous point mutations have resulted in amino acid substitutions at many sites in the polypeptide. The polymorphisms in AMA1 have been attributed to the diversifying selection pressure of the protective immune responses. It was therefore of interest to investigate the impact of sequence diversity in P. falciparum AMA1 on the ability of anti-AMA1 antibodies to inhibit the invasion of erythrocytes in vitro by P. falciparum merozoites. For these studies, we used antibodies to recombinant P. falciparum 3D7 AMA1 ectodomain, which was prepared for testing in early clinical trials. Antibodies were raised in rabbits to the antigen formulated in Montanide ISA720, and human antibodies to AMA1 were isolated by affinity purification from the plasma of adults living in regions of Papua New Guinea where malaria is endemic. Both rabbit and human anti-AMA1 antibodies were found to be strongly inhibitory to the invasion of erythrocytes by merozoites from both the homologous and two heterologous lines of P. falciparum. The inhibitory antibodies targeted both conserved and strain-specific epitopes within the ectodomain of AMA1; however, it appears that the majority of these antibodies reacted with strain-specific epitopes in domain I, the N-terminal disulfide-bonded domain, which is the most polymorphic region of AMA1.

* Corresponding author. Mailing address: Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Victoria, Australia, 3052. Phone: 61-3-93452555. Fax: 61-3-93470852. E-mail: hodder{at}wehi.edu.au.

Infection and Immunity, May 2001, p. 3286-3294, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3286-3294.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Miura, K., Zhou, H., Diouf, A., Moretz, S. E., Fay, M. P., Miller, L. H., Martin, L. B., Pierce, M. A., Ellis, R. D., Mullen, G. E. D., Long, C. A. (2009). Anti-Apical-Membrane-Antigen-1 Antibody Is More Effective than Anti-42-Kilodalton-Merozoite-Surface-Protein-1 Antibody in Inhibiting Plasmodium falciparum Growth, as Determined by the In Vitro Growth Inhibition Assay. CVI 16: 963-968 [Abstract] [Full Text]  
  • Harris, K. S., Casey, J. L., Coley, A. M., Karas, J. A., Sabo, J. K., Tan, Y. Y., Dolezal, O., Norton, R. S., Hughes, A. B., Scanlon, D., Foley, M. (2009). Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by Comprehensive N-Methyl Scanning. J. Biol. Chem. 284: 9361-9371 [Abstract] [Full Text]  
  • Stanisic, D. I., Richards, J. S., McCallum, F. J., Michon, P., King, C. L., Schoepflin, S., Gilson, P. R., Murphy, V. J., Anders, R. F., Mueller, I., Beeson, J. G. (2009). Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness. Infect. Immun. 77: 1165-1174 [Abstract] [Full Text]  
  • Doolan, D. L., Dobano, C., Baird, J. K. (2009). Acquired Immunity to Malaria. Clin. Microbiol. Rev. 22: 13-36 [Abstract] [Full Text]  
  • Miura, K., Zhou, H., Moretz, S. E., Diouf, A., Thera, M. A., Dolo, A., Doumbo, O., Malkin, E., Diemert, D., Miller, L. H., Mullen, G. E. D., Long, C. A. (2008). Comparison of Biological Activity of Human Anti-Apical Membrane Antigen-1 Antibodies Induced by Natural Infection and Vaccination. J. Immunol. 181: 8776-8783 [Abstract] [Full Text]  
  • Fairlie, W. D., Spurck, T. P., McCoubrie, J. E., Gilson, P. R., Miller, S. K., McFadden, G. I., Malby, R., Crabb, B. S., Hodder, A. N. (2008). Inhibition of Malaria Parasite Development by a Cyclic Peptide That Targets the Vital Parasite Protein SERA5. Infect. Immun. 76: 4332-4344 [Abstract] [Full Text]  
  • Tsuboi, T., Takeo, S., Iriko, H., Jin, L., Tsuchimochi, M., Matsuda, S., Han, E.-T., Otsuki, H., Kaneko, O., Sattabongkot, J., Udomsangpetch, R., Sawasaki, T., Torii, M., Endo, Y. (2008). Wheat Germ Cell-Free System-Based Production of Malaria Proteins for Discovery of Novel Vaccine Candidates. Infect. Immun. 76: 1702-1708 [Abstract] [Full Text]  
  • Miura, K., Zhou, H., Muratova, O. V., Orcutt, A. C., Giersing, B., Miller, L. H., Long, C. A. (2007). In Immunization with Plasmodium falciparum Apical Membrane Antigen 1, the Specificity of Antibodies Depends on the Species Immunized. Infect. Immun. 75: 5827-5836 [Abstract] [Full Text]  
  • Faber, B. W., Remarque, E. J., Morgan, W. D., Kocken, C. H. M., Holder, A. A., Thomas, A. W. (2007). Malaria Vaccine-Related Benefits of a Single Protein Comprising Plasmodium falciparum Apical Membrane Antigen 1 Domains I and II Fused to a Modified Form of the 19-Kilodalton C-Terminal Fragment of Merozoite Surface Protein 1. Infect. Immun. 75: 5947-5955 [Abstract] [Full Text]  
  • Dutta, S., Lee, S. Y., Batchelor, A. H., Lanar, D. E. (2007). Structural basis of antigenic escape of a malaria vaccine candidate. Proc. Natl. Acad. Sci. USA 104: 12488-12493 [Abstract] [Full Text]  
  • Gray, J. C., Corran, P. H., Mangia, E., Gaunt, M. W., Li, Q., Tetteh, K. K.A., Polley, S. D., Conway, D. J., Holder, A. A., Bacarese-Hamilton, T., Riley, E. M., Crisanti, A. (2007). Profiling the Antibody Immune Response against Blood Stage Malaria Vaccine Candidates. Clin. Chem. 53: 1244-1253 [Abstract] [Full Text]  
  • Collins, C. R., Withers-Martinez, C., Bentley, G. A., Batchelor, A. H., Thomas, A. W., Blackman, M. J. (2007). Fine Mapping of an Epitope Recognized by an Invasion-inhibitory Monoclonal Antibody on the Malaria Vaccine Candidate Apical Membrane Antigen 1. J. Biol. Chem. 282: 7431-7441 [Abstract] [Full Text]  
  • Metenou, S., Suguitan, A. L. Jr., Long, C., Leke, R. G. F., Taylor, D. W. (2007). Fetal Immune Responses to Plasmodium falciparum Antigens in a Malaria-Endemic Region of Cameroon. J. Immunol. 178: 2770-2777 [Abstract] [Full Text]  
  • Coley, A. M., Parisi, K., Masciantonio, R., Hoeck, J., Casey, J. L., Murphy, V. J., Harris, K. S., Batchelor, A. H., Anders, R. F., Foley, M. (2006). The Most Polymorphic Residue on Plasmodium falciparum Apical Membrane Antigen 1 Determines Binding of an Invasion-Inhibitory Antibody.. Infect. Immun. 74: 2628-2636 [Abstract] [Full Text]  
  • Wickramarachchi, T., Premaratne, P. H., Perera, K. L. R. L., Bandara, S., Kocken, C. H. M., Thomas, A. W., Handunnetti, S. M., Udagama-Randeniya, P. V. (2006). Natural Human Antibody Responses to Plasmodium vivax Apical Membrane Antigen 1 under Low Transmission and Unstable Malaria Conditions in Sri Lanka. Infect. Immun. 74: 798-801 [Abstract] [Full Text]  
  • Sanders, P. R., Gilson, P. R., Cantin, G. T., Greenbaum, D. C., Nebl, T., Carucci, D. J., McConville, M. J., Schofield, L., Hodder, A. N., Yates, J. R. III, Crabb, B. S. (2005). Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum. J. Biol. Chem. 280: 40169-40176 [Abstract] [Full Text]  
  • Shi, Q., Cernetich, A., Daly, T. M., Galvan, G., Vaidya, A. B., Bergman, L. W., Burns, J. M. Jr (2005). Alteration in Host Cell Tropism Limits the Efficacy of Immunization with a Surface Protein of Malaria Merozoites. Infect. Immun. 73: 6363-6371 [Abstract] [Full Text]  
  • Harris, K. S., Casey, J. L., Coley, A. M., Masciantonio, R., Sabo, J. K., Keizer, D. W., Lee, E. F., McMahon, A., Norton, R. S., Anders, R. F., Foley, M. (2005). Binding Hot Spot for Invasion Inhibitory Molecules on Plasmodium falciparum Apical Membrane Antigen 1. Infect. Immun. 73: 6981-6989 [Abstract] [Full Text]  
  • Bai, T., Becker, M., Gupta, A., Strike, P., Murphy, V. J., Anders, R. F., Batchelor, A. H. (2005). Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket. Proc. Natl. Acad. Sci. USA 102: 12736-12741 [Abstract] [Full Text]  
  • Tetteh, K. K. A., Cavanagh, D. R., Corran, P., Musonda, R., McBride, J. S., Conway, D. J. (2005). Extensive Antigenic Polymorphism within the Repeat Sequence of the Plasmodium falciparum Merozoite Surface Protein 1 Block 2 Is Incorporated in a Minimal Polyvalent Immunogen. Infect. Immun. 73: 5928-5935 [Abstract] [Full Text]  
  • Giersing, B., Miura, K., Shimp, R., Wang, J., Zhou, H., Orcutt, A., Stowers, A., Saul, A., Miller, L. H., Long, C., Singh, S. (2005). Posttranslational Modification of Recombinant Plasmodium falciparum Apical Membrane Antigen 1: Impact on Functional Immune Responses to a Malaria Vaccine Candidate. Infect. Immun. 73: 3963-3970 [Abstract] [Full Text]  
  • Malkin, E. M., Diemert, D. J., McArthur, J. H., Perreault, J. R., Miles, A. P., Giersing, B. K., Mullen, G. E., Orcutt, A., Muratova, O., Awkal, M., Zhou, H., Wang, J., Stowers, A., Long, C. A., Mahanty, S., Miller, L. H., Saul, A., Durbin, A. P. (2005). Phase 1 Clinical Trial of Apical Membrane Antigen 1: an Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria. Infect. Immun. 73: 3677-3685 [Abstract] [Full Text]  
  • Pizarro, J. C., Normand, B. V.-L., Chesne-Seck, M.-L., Collins, C. R., Withers-Martinez, C., Hackett, F., Blackman, M. J., Faber, B. W., Remarque, E. J., Kocken, C. H. M., Thomas, A. W., Bentley, G. A. (2005). Crystal Structure of the Malaria Vaccine Candidate Apical Membrane Antigen 1. Science 308: 408-411 [Abstract] [Full Text]  
  • Drakeley, C. J., Corran, P. H., Coleman, P. G., Tongren, J. E., McDonald, S. L. R., Carneiro, I., Malima, R., Lusingu, J., Manjurano, A., Nkya, W. M. M., Lemnge, M. M., Cox, J., Reyburn, H., Riley, E. M. (2005). Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure. Proc. Natl. Acad. Sci. USA 102: 5108-5113 [Abstract] [Full Text]  
  • Dutta, S., Haynes, J. D., Barbosa, A., Ware, L. A., Snavely, J. D., Moch, J. K., Thomas, A. W., Lanar, D. E. (2005). Mode of Action of Invasion-Inhibitory Antibodies Directed against Apical Membrane Antigen 1 of Plasmodium falciparum. Infect. Immun. 73: 2116-2122 [Abstract] [Full Text]  
  • Healer, J., Triglia, T., Hodder, A. N., Gemmill, A. W., Cowman, A. F. (2005). Functional Analysis of Plasmodium falciparum Apical Membrane Antigen 1 Utilizing Interspecies Domains. Infect. Immun. 73: 2444-2451 [Abstract] [Full Text]  
  • Cortes, A., Mellombo, M., Masciantonio, R., Murphy, V. J., Reeder, J. C., Anders, R. F. (2005). Allele Specificity of Naturally Acquired Antibody Responses against Plasmodium falciparum Apical Membrane Antigen 1. Infect. Immun. 73: 422-430 [Abstract] [Full Text]  
  • Burns, J. M. Jr., Flaherty, P. R., Nanavati, P., Weidanz, W. P. (2004). Protection against Plasmodium chabaudi Malaria Induced by Immunization with Apical Membrane Antigen 1 and Merozoite Surface Protein 1 in the Absence of Gamma Interferon or Interleukin-4. Infect. Immun. 72: 5605-5612 [Abstract] [Full Text]  
  • Lalitha, P. V., Ware, L. A., Barbosa, A., Dutta, S., Moch, J. K., Haynes, J. D., Fileta, B. B., White, C. E., Lanar, D. E. (2004). Production of the Subdomains of the Plasmodium falciparum Apical Membrane Antigen 1 Ectodomain and Analysis of the Immune Response. Infect. Immun. 72: 4464-4470 [Abstract] [Full Text]  
  • BALLOU, W. R., AREVALO-HERRERA, M., CARUCCI, D., RICHIE, T. L., CORRADIN, G., DIGGS, C., DRUILHE, P., GIERSING, B. K., SAUL, A., HEPPNER, D. G., KESTER, K. E., LANAR, D. E., LYON, J., HILL, A. V. S., PAN, W., COHEN, J. D. (2004). UPDATE ON THE CLINICAL DEVELOPMENT OF CANDIDATE MALARIA VACCINES. Am J Trop Med Hyg 71: 239-247 [Abstract] [Full Text]  
  • Johnson, A. H., Leke, R. G. F., Mendell, N. R., Shon, D., Suh, Y. J., Bomba-Nkolo, D., Tchinda, V., Kouontchou, S., Thuita, L. W., van der Wel, A. M., Thomas, A., Stowers, A., Saul, A., Zhou, A., Taylor, D. W., Quakyi, I. A. (2004). Human Leukocyte Antigen Class II Alleles Influence Levels of Antibodies to the Plasmodium falciparum Asexual-Stage Apical Membrane Antigen 1 but Not to Merozoite Surface Antigen 2 and Merozoite Surface Protein 1. Infect. Immun. 72: 2762-2771 [Abstract] [Full Text]  
  • Pearce, J. A., Triglia, T., Hodder, A. N., Jackson, D. C., Cowman, A. F., Anders, R. F. (2004). Plasmodium falciparum Merozoite Surface Protein 6 Is a Dimorphic Antigen. Infect. Immun. 72: 2321-2328 [Abstract] [Full Text]  
  • Silvie, O., Franetich, J.-F., Charrin, S., Mueller, M. S., Siau, A., Bodescot, M., Rubinstein, E., Hannoun, L., Charoenvit, Y., Kocken, C. H., Thomas, A. W., van Gemert, G.-J., Sauerwein, R. W., Blackman, M. J., Anders, R. F., Pluschke, G., Mazier, D. (2004). A Role for Apical Membrane Antigen 1 during Invasion of Hepatocytes by Plasmodium falciparum Sporozoites. J. Biol. Chem. 279: 9490-9496 [Abstract] [Full Text]  
  • Casey, J. L., Coley, A. M., Anders, R. F., Murphy, V. J., Humberstone, K. S., Thomas, A. W., Foley, M. (2004). Antibodies to Malaria Peptide Mimics Inhibit Plasmodium falciparum Invasion of Erythrocytes. Infect. Immun. 72: 1126-1134 [Abstract] [Full Text]  
  • Hodder, A. N., Drew, D. R., Epa, V. C., Delorenzi, M., Bourgon, R., Miller, S. K., Moritz, R. L., Frecklington, D. F., Simpson, R. J., Speed, T. P., Pike, R. N., Crabb, B. S. (2003). Enzymic, Phylogenetic, and Structural Characterization of the Unusual Papain-like Protease Domain of Plasmodium falciparum SERA5. J. Biol. Chem. 278: 48169-48177 [Abstract] [Full Text]  
  • Mahanty, S., Saul, A., Miller, L. H. (2003). Progress in the development of recombinant and synthetic blood-stage malaria vaccines. J. Exp. Biol. 206: 3781-3788 [Abstract] [Full Text]  
  • Dutta, S., Haynes, J. D., Moch, J. K., Barbosa, A., Lanar, D. E. (2003). Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites. Proc. Natl. Acad. Sci. USA 100: 12295-12300 [Abstract] [Full Text]  
  • Polley, S. D., Chokejindachai, W., Conway, D. J. (2003). Allele Frequency-Based Analyses Robustly Map Sequence Sites Under Balancing Selection in a Malaria Vaccine Candidate Antigen. Genetics 165: 555-561 [Abstract] [Full Text]  
  • Rainczuk, A., Scorza, T., Smooker, P. M., Spithill, T. W. (2003). Induction of Specific T-Cell Responses, Opsonizing Antibodies, and Protection against Plasmodium chabaudi adami Infection in Mice Vaccinated with Genomic Expression Libraries Expressed in Targeted and Secretory DNA Vectors. Infect. Immun. 71: 4506-4515 [Abstract] [Full Text]  
  • Mueller, M. S., Renard, A., Boato, F., Vogel, D., Naegeli, M., Zurbriggen, R., Robinson, J. A., Pluschke, G. (2003). Induction of Parasite Growth-Inhibitory Antibodies by a Virosomal Formulation of a Peptidomimetic of Loop I from Domain III of Plasmodium falciparum Apical Membrane Antigen 1. Infect. Immun. 71: 4749-4758 [Abstract] [Full Text]  
  • Cortes, A., Mellombo, M., Mueller, I., Benet, A., Reeder, J. C., Anders, R. F. (2003). Geographical Structure of Diversity and Differences between Symptomatic and Asymptomatic Infections for Plasmodium falciparum Vaccine Candidate AMA1. Infect. Immun. 71: 1416-1426 [Abstract] [Full Text]  
  • Li, F., Dluzewski, A., Coley, A. M., Thomas, A., Tilley, L., Anders, R. F., Foley, M. (2002). Phage-displayed Peptides Bind to the Malarial Protein Apical Membrane Antigen-1 and Inhibit the Merozoite Invasion of Host Erythrocytes. J. Biol. Chem. 277: 50303-50310 [Abstract] [Full Text]  
  • Kennedy, M. C., Wang, J., Zhang, Y., Miles, A. P., Chitsaz, F., Saul, A., Long, C. A., Miller, L. H., Stowers, A. W. (2002). In Vitro Studies with Recombinant Plasmodium falciparum Apical Membrane Antigen 1 (AMA1): Production and Activity of an AMA1 Vaccine and Generation of a Multiallelic Response. Infect. Immun. 70: 6948-6960 [Abstract] [Full Text]  
  • Stowers, A. W., Kennedy, M. C., Keegan, B. P., Saul, A., Long, C. A., Miller, L. H. (2002). Vaccination of Monkeys with Recombinant Plasmodium falciparum Apical Membrane Antigen 1 Confers Protection against Blood-Stage Malaria. Infect. Immun. 70: 6961-6967 [Abstract] [Full Text]  
  • Healer, J., Crawford, S., Ralph, S., McFadden, G., Cowman, A. F. (2002). Independent Translocation of Two Micronemal Proteins in Developing Plasmodium falciparum Merozoites. Infect. Immun. 70: 5751-5758 [Abstract] [Full Text]  
  • Kocken, C. H. M., Withers-Martinez, C., Dubbeld, M. A., van der Wel, A., Hackett, F., Blackman, M. J., Thomas, A. W. (2002). High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion. Infect. Immun. 70: 4471-4476 [Abstract] [Full Text]  
  • Moorthy, V., Hill, A. V S (2002). Malaria vaccines. Br Med Bull 62: 59-72 [Abstract] [Full Text]  
  • Dutta, S., Lalitha, P. V., Ware, L. A., Barbosa, A., Moch, J. K., Vassell, M. A., Fileta, B. B., Kitov, S., Kolodny, N., Heppner, D. G., Haynes, J. D., Lanar, D. E. (2002). Purification, Characterization, and Immunogenicity of the Refolded Ectodomain of the Plasmodium falciparum Apical Membrane Antigen 1 Expressed in Escherichia coli. Infect. Immun. 70: 3101-3110 [Abstract] [Full Text]  
  • Saul, A., Miller, L. H. (2001). A Robust Neutralization Test for Plasmodium falciparum Malaria. JEM 193: f51-f54 [Full Text]  
  • O'Donnell, R. A., de Koning-Ward, T. F., Burt, R. A., Bockarie, M., Reeder, J. C., Cowman, A. F., Crabb, B. S. (2001). Antibodies against Merozoite Surface Protein (Msp)-119 Are a Major Component of the Invasion-Inhibitory Response in Individuals Immune to Malaria. JEM 193: 1403-1412 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»