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Infection and Immunity, May 2001, p. 3410-3412, Vol. 69, No. 5
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.5.3410-3412.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Passive Immunization with Melanin-Binding Monoclonal
Antibodies Prolongs Survival of Mice with Lethal Cryptococcus
neoformans Infection
Ángel L.
Rosas,1
Joshua D.
Nosanchuk,2 and
Arturo
Casadevall1,2,*
Department of Microbiology & Immunology1 and Division of Infectious
Diseases of the Department of Medicine,2 Albert
Einstein College of Medicine, Bronx, New York 10461
Received 21 December 2000/Returned for modification 29 January
2001/Accepted 15 February 2001
Passive immunization with monoclonal antibodies (MAbs) to melanin
prolonged the survival of and reduced the fungal burden in
Cryptococcus neoformans-infected mice in comparison to
controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of
antibody-mediated protection.
*
Corresponding author. Mailing address: Albert Einstein
College of Medicine, Golding 701, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-3730. Fax: (718) 430-8701. E-mail:
casadeva{at}aecom.yu.edu.
Infection and Immunity, May 2001, p. 3410-3412, Vol. 69, No. 5
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.5.3410-3412.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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