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Infection and Immunity, May 2001, p. 3410-3412, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3410-3412.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Passive Immunization with Melanin-Binding Monoclonal Antibodies Prolongs Survival of Mice with Lethal Cryptococcus neoformans Infection

Ángel L. Rosas,1 Joshua D. Nosanchuk,2 and Arturo Casadevall1,2,*

Department of Microbiology & Immunology1 and Division of Infectious Diseases of the Department of Medicine,2 Albert Einstein College of Medicine, Bronx, New York 10461

Received 21 December 2000/Returned for modification 29 January 2001/Accepted 15 February 2001

Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, Golding 701, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-3730. Fax: (718) 430-8701. E-mail: casadeva{at}aecom.yu.edu.

Infection and Immunity, May 2001, p. 3410-3412, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3410-3412.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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