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Infection and Immunity, May 2001, p. 3423-3426, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3423-3426.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Key Role of Teichoic Acid Net Charge in Staphylococcus aureus Colonization of Artificial Surfaces

Matthias Gross, Sarah E. Cramton, Friedrich Götz, and Andreas Peschel*

Microbial Genetics, University of Tübingen, D-72076 Tübingen, Germany

Received 31 October 2000/Returned for modification 8 January 2001/Accepted 12 February 2001

Staphylococcus aureus is responsible for a large percentage of infections associated with implanted biomedical devices. The molecular basis of primary adhesion to artificial surfaces is not yet understood. Here, we demonstrate that teichoic acids, highly charged cell wall polymers, play a key role in the first step of biofilm formation. An S. aureus mutant bearing a stronger negative surface charge due to the lack of D-alanine esters in its teichoic acids can no longer colonize polystyrene or glass. The mutation abrogates primary adhesion to plastic while production of the glucosamine-based polymer involved in later steps of biofilm formation is not affected. Our data suggest that repulsive electrostatic forces can lead to reduced staphylococcal biofilm formation, which could have considerable impact on the design of novel implanted materials.

* Mailing address: Microbial Genetics, University of Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. Phone: 49-7071-297-2611. Fax: 49-7071-29-5065. E-mail: andreas.peschel{at}uni-tuebingen.de.

Infection and Immunity, May 2001, p. 3423-3426, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3423-3426.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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