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Infection and Immunity, May 2001, p. 3427-3430, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3427-3430.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Protective Cytotoxic T Lymphocyte Responses Induced by DNA Immunization against Immunodominant and Subdominant Epitopes of Listeria monocytogenes Are Noncompetitive

Takashi Yamada,¹ Hiroshi Uchiyama,¹ Toshi Nagata,² Masato Uchijima,² Takafumi Suda,¹ Kingo Chida,¹ Hirotoshi Nakamura,¹ and Yukio Koide^2,*

Second Department of Internal Medicine¹ and Department of Microbiology and Immunology,² Hamamatsu Univeristy School of Medicine, Hamamatsu 431-3192, Japan

Received 6 August 2000/Returned for modification 25 October 2000/Accepted 2 February 2001

Taking advantage of the fact that plasmid DNA encoding a single cytotoxic T lymphocyte (CTL) epitope can induce CTLs, we examined the influence of T-cell responses to dominant epitopes on those to a subdominant epitope derived from Listeria monocytogenes. Our data suggest that interaction between T cells against dominant and subdominant epitopes does not operate in the generation of the hierarchy. Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity.

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^* Corresponding author. Mailing address: Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, Japan. Phone: 81-53-435-2334. Fax: 81-53-435-2335. E-mail: koidelb{at}hama-med.ac.jp.

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Infection and Immunity, May 2001, p. 3427-3430, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3427-3430.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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