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Infection and Immunity, May 2001, p. 3427-3430, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3427-3430.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Protective Cytotoxic T Lymphocyte Responses Induced by DNA Immunization against Immunodominant and Subdominant Epitopes of Listeria monocytogenes Are Noncompetitive

Takashi Yamada,1 Hiroshi Uchiyama,1 Toshi Nagata,2 Masato Uchijima,2 Takafumi Suda,1 Kingo Chida,1 Hirotoshi Nakamura,1 and Yukio Koide2,*

Second Department of Internal Medicine1 and Department of Microbiology and Immunology,2 Hamamatsu Univeristy School of Medicine, Hamamatsu 431-3192, Japan

Received 6 August 2000/Returned for modification 25 October 2000/Accepted 2 February 2001

Taking advantage of the fact that plasmid DNA encoding a single cytotoxic T lymphocyte (CTL) epitope can induce CTLs, we examined the influence of T-cell responses to dominant epitopes on those to a subdominant epitope derived from Listeria monocytogenes. Our data suggest that interaction between T cells against dominant and subdominant epitopes does not operate in the generation of the hierarchy. Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, Japan. Phone: 81-53-435-2334. Fax: 81-53-435-2335. E-mail: koidelb{at}hama-med.ac.jp.

Infection and Immunity, May 2001, p. 3427-3430, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3427-3430.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Igwe, E. I., Geginat, G., Russmann, H. (2002). Concomitant Cytosolic Delivery of Two Immunodominant Listerial Antigens by Salmonella enterica Serovar Typhimurium Confers Superior Protection against Murine Listeriosis. Infect. Immun. 70: 7114-7119 [Abstract] [Full Text]  
  • Nagata, T., Aoshi, T., Suzuki, M., Uchijima, M., Kim, Y.-H., Yang, Z., Koide, Y. (2002). Induction of Protective Immunity to Listeria monocytogenes by Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain. Infect. Immun. 70: 2676-2680 [Abstract] [Full Text]  


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