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Infection and Immunity, May 2001, p. 3431-3434, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3431-3434.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Periodontal Pathogens Produce Quorum Sensing Signal Molecules

Jorge Frias,* Ester Olle, and Merce Alsina

Department of Microbiology, DENTAID, 08290 Cerdanyola, Barcelona, Spain

Received 21 September 2000/Returned for modification 9 December 2000/Accepted 10 January 2001

Different species of bacteria important in the composition of dental plaque were tested for production of extracellular autoinducer-like activities that stimulate the expression of the luminescence genes in Vibrio harveyi. Several strains of Prevotella intermedia, Fusobacterium nucleatum, and Porphyromonas gingivalis were found to produce such activities. Interestingly, these bacteria belong to the same phylogenetic group, and they are periodontal pathogens important in the development of periodontal disease. They specifically produce extracellular signaling molecule related autoinducer-2 from V. haveyi. Nevertheless, they seem to be unable to produce homologues of acyl-homoserine lactones. Furthermore, Escherichia coli DH5alpha can be complemented by the introduction of a P. gingivalis gene with high homology to the luxS gene, which has been called luxSP.g..

* Corresponding author. Mailing address: DENTAID, Parc Tecnològic del Vallès, Ronda Can Fatjó, 10, 08290 Cerdanyola, Barcelona, Spain. Phone: (393) 580-9494. Fax: (393) 590-9004. E-mail: frias{at}dentaid.ptv.es.

Infection and Immunity, May 2001, p. 3431-3434, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3431-3434.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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