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Infection and Immunity, May 2001, p. 3494-3496, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3494-3496.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Pneumolysin Potentiates Production of Prostaglandin E2 and Leukotriene B4 by Human Neutrophils

Riana Cockeran,1 Helen C. Steel,1 Timothy J. Mitchell,2 Charles Feldman,3 and Ronald Anderson1,*

Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Institute for Pathology, University of Pretoria, Pretoria,1 and Division of Pulmonology, Johannesburg Hospital and University of the Witwatersrand, Johannesburg,3 South Africa, and Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland2

Received 16 January 2001/Returned for modification 5 February 2001/Accepted 22 February 2001

Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E2 and leukotriene B4 by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

* Corresponding author. Mailing address: Institute for Pathology, P.O. Box 2034, Pretoria 0001, South Africa. Phone: 27-12-319 2425. Fax: 27-12-323 0732. E-mail: randerso{at}postillion.up.ac.za or rcockera{at}postillion.up.ac.za.

Infection and Immunity, May 2001, p. 3494-3496, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3494-3496.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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