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Infection and Immunity, May 2001, p. 3497-3501, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3497-3501.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Contribution of CD8+ T Cells to Gamma Interferon Production in Human Tuberculosis

Homayoun Shams,1 Benjamin Wizel,1,2 Stephen E. Weis,3 Buka Samten,1 and Peter F. Barnes1,4,5,*

Center for Pulmonary and Infectious Disease Control,1 Departments of Immunology,2 Medicine,4 and Cell Biology,5 University of Texas Health Center, Tyler, and Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth,3 Texas

Received 28 September 2000/Returned for modification 22 November 2000/Accepted 20 February 2001

The proportions of peripheral blood mononuclear cells (PBMC), CD4+ T cells, and CD8+ T cells that produce gamma interferon (IFN-gamma ) in response to Mycobacterium tuberculosis were markedly reduced in tuberculosis patients, particularly in those with severe disease. Depletion of CD4+ but not CD8+ cells prior to stimulation of PBMC with M. tuberculosis abolished IFN-gamma production. These results show that (i) IFN-gamma production by CD8+ and CD4+ cells correlates with the clinical manifestations of M. tuberculosis infection and (ii) IFN-gamma production by CD8+ cells depends on CD4+ cells.

* Corresponding author. Mailing address: CPIDC, University of Texas Health Center, 11937 U.S. Hwy. 271, Tyler, TX 75708-3154. Phone: (903) 877-7790. Fax: (903) 877-5516. E-mail: Peter.Barnes{at}uthct.edu.

Infection and Immunity, May 2001, p. 3497-3501, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3497-3501.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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