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Infection and Immunity, May 2001, p. 3519-3522, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3519-3522.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Selection for Urease Activity during Helicobacter pylori Infection of Rhesus Macaques (Macaca mulatta)

Lori M. Hansen and Jay V. Solnick*

Departments of Internal Medicine and Medical Microbiology and Immunology, University of California, Davis School of Medicine, Davis, California 95616

Received 7 September 2000/Returned for modification 12 December 2000/Accepted 11 February 2001

Helicobacter pylori strain J166 recovered from experimentally inoculated rhesus monkeys had up to a 250-fold-increased urease activity over that before inoculation. This was found to result from the selection of urease positive J166 clones from a heterogenous inoculum, which was predominantly urease negative due to a 1-bp insertion in the ureA gene. These results confirm the importance of urease for H. pylori colonization. Strain J166 is particularly well adapted to the rhesus monkey, since it colonized preferentially despite the fact that less than 0.1% of the inoculum was urease positive.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, 3140 Tupper Hall, University of California, Davis, Davis, CA 95616. Phone: (530) 752-1333. Fax: (530) 752-8692. E-mail: jvsolnick{at}ucdavis.edu.

Infection and Immunity, May 2001, p. 3519-3522, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3519-3522.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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