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Infection and Immunity, June 2001, p. 3635-3645, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.3635-3645.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Plasmodium falciparum Homologue of the Genes for Plasmodium vivax and Plasmodium yoelii Adhesive Proteins, Which Is Transcribed but Not Translated

Helen M. Taylor,1,* Tony Triglia,2 Jenny Thompson,2 Mohammed Sajid,1,dagger Ruth Fowler,3 Mark E. Wickham,2 Alan F. Cowman,2 and Anthony A. Holder1

National Institute for Medical Research, Mill Hill, London NW7 1AA,1 and Department of Immunobiology, Guy's, King's & St. Thomas' Medical School, London SE1 9RT,3 United Kingdom, and The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia2

Received 15 December 2000/Returned for modification 12 February 2001/Accepted 28 February 2001

The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte invasion. Here we described a member of the gene family found in P. falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears not to be translated, probably due to two reading frameshifts at the 5' end of the gene.

* Corresponding author. Mailing address: Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom. Phone: 44-208-959-3666. Fax: 44-208-913-8593. E-mail: htaylor{at}nimr.mrc.ac.uk.

dagger Present address: Tropical Disease Research Unit, University of California, VA Medical Center, San Francisco, CA 94121.

Infection and Immunity, June 2001, p. 3635-3645, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.3635-3645.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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