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Infection and Immunity, June 2001, p. 3877-3882, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.3877-3882.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Staphylococcus aureus Induces Release of Bradykinin in Human Plasma

Eva Mattsson,1,2,* Heiko Herwald,1 Henning Cramer,1,dagger Kristin Persson,1 Ulf Sjöbring,3 and Lars Björck1

Departments of Cell and Molecular Biology,1 Medical Microbiology and Infectious Diseases,2 and Laboratory Medicine,3 Lund University, Lund, Sweden

Received 9 October 2000/Returned for modification 11 December 2000/Accepted 19 March 2001

Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent proinflammatory and vasoactive peptide bradykinin. In contrast, no such effect was recorded with Streptococcus pneumoniae. In the activation of the contact system, blood coagulation factor XII and plasma kallikrein play central roles, and a specific inhibitor of these serine proteinases inhibited the release of bradykinin by S. aureus in human plasma. Furthermore, fragments of the cofactor H-kininogen of the contact system efficiently blocked bradykinin release. The results suggest that activation of the contact system at the surface of S. aureus and the subsequent release of bradykinin could contribute to the hypovolemic hypotension seen in patients with severe S. aureus sepsis. The data also suggest that the contact system could be used as a target in the treatment of S. aureus infections.

* Corresponding author. Mailing address: Department of Cell and Molecular Biology, BMC B14, Tornav. 10, S-221 84 Lund, Sweden. Phone: 46-46-2220720. Fax: 46-46-157756. E-mail: fam.mattsson{at}delta.telenordia.se.

dagger Present address: SKM-Oncology Research GmbH, D-90429 Nurnberg, Germany.

Infection and Immunity, June 2001, p. 3877-3882, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.3877-3882.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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