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Infection and Immunity, June 2001, p. 4116-4119, Vol. 69, No. 6
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.6.4116-4119.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Effects of Exogenous Interleukin-6 during
Pseudomonas aeruginosa Corneal Infection
Nerida
Cole,1,2
Mark
Krockenberger,2
Shisan
Bao,2
Kenneth W.
Beagley,3
Alan J.
Husband,2 and
Mark
Willcox1,*
Co-Operative Research Center for Eye Research
and Technology, Cornea and Contact Lens Research Unit and School of
Optometry, University of New South Wales,1 and
Department of Veterinary Anatomy and Pathology, University of
Sydney,2 Sydney, and Discipline of
Pathology, Faculty of Medicine, The University of Newcastle,
Newcastle,3 Australia
Received 29 December 2000/Returned for modification 27 February
2001/Accepted 5 March 2001
Lack of interleukin-6 (IL-6) during Pseudomonas
aeruginosa corneal infection leads to more severe disease with
changes in neutrophil recruitment. Exogenous IL-6 leads to increased
efficiency of neutrophil recruitment and reduced bacterial loads in
corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We
conclude that effective recruitment of neutrophils into the cornea is
dependent on the production of IL-6 and that early augmentation of IL-6
may be protective in corneal infection.
*
Corresponding author. Mailing address: CRCERT and
CCLRU, School of Optometry, University of New South Wales, Sydney, NSW
2052, Australia. Phone: 61 2 9385 7524. Fax: 61 2 9385 7401. E-mail: m.willcox{at}cclru.unsw.edu.au.
Infection and Immunity, June 2001, p. 4116-4119, Vol. 69, No. 6
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.6.4116-4119.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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