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Infection and Immunity, June 2001, p. 4116-4119, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4116-4119.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Effects of Exogenous Interleukin-6 during Pseudomonas aeruginosa Corneal Infection

Nerida Cole,1,2 Mark Krockenberger,2 Shisan Bao,2 Kenneth W. Beagley,3 Alan J. Husband,2 and Mark Willcox1,*

Co-Operative Research Center for Eye Research and Technology, Cornea and Contact Lens Research Unit and School of Optometry, University of New South Wales,1 and Department of Veterinary Anatomy and Pathology, University of Sydney,2 Sydney, and Discipline of Pathology, Faculty of Medicine, The University of Newcastle, Newcastle,3 Australia

Received 29 December 2000/Returned for modification 27 February 2001/Accepted 5 March 2001

Lack of interleukin-6 (IL-6) during Pseudomonas aeruginosa corneal infection leads to more severe disease with changes in neutrophil recruitment. Exogenous IL-6 leads to increased efficiency of neutrophil recruitment and reduced bacterial loads in corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We conclude that effective recruitment of neutrophils into the cornea is dependent on the production of IL-6 and that early augmentation of IL-6 may be protective in corneal infection.

* Corresponding author. Mailing address: CRCERT and CCLRU, School of Optometry, University of New South Wales, Sydney, NSW 2052, Australia. Phone: 61 2 9385 7524. Fax: 61 2 9385 7401. E-mail: m.willcox{at}cclru.unsw.edu.au.

Infection and Immunity, June 2001, p. 4116-4119, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4116-4119.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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