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Infection and Immunity, June 2001, p. 4120-4124, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4120-4124.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Vaccination with Bordetella pertussis-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection

Annie George-Chandy,1 Nathalie Mielcarek,2 Inger Nordström,1 Jan Holmgren,1 and Kristina Eriksson1,*

Department of Medical Microbiology & Immunology, Göteborg University, Göteborg, Sweden,1 and INSERM U447, Institut Pasteur de Lille, Lille, France2

Received 9 October 2000/Returned for modification 7 December 2000/Accepted 12 March 2001

This study demonstrates for the first time that vaccination with either autologous or heterologous dendritic cells (DC) pulsed with specific antigen induces protective immune responses against noninvasive bacteria, namely Bordetella pertussis. The DC-mediated protection is associated with strong B. pertussis-specific immunoglobulin G (IgG) and IgA responses in the lung.

* Corresponding author. Mailing address: Department of Medical Microbiology & Immunology, Guldhedsgatan 10A, 413 46 Göteborg, Sweden. Phone: 46-31-3424761. Fax: 46-31-820160. E-mail: kristina.eriksson{at}microbio.gu.se.

Infection and Immunity, June 2001, p. 4120-4124, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4120-4124.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.