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Infection and Immunity, June 2001, p. 4141-4145, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4141-4145.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Pyrogenicity and Cytokine-Inducing Properties of Streptococcus pyogenes Superantigens: Comparative Study of Streptococcal Mitogenic Exotoxin Z and Pyrogenic Exotoxin A

Heide Müller-Alouf,1 Thomas Proft,2 Thomas M. Zollner,3 Dieter Gerlach,4 Eric Champagne,5 Pierre Desreumaux,6 Catherine Fitting,7 Christiane Geoffroy-Fauvet,8 Joseph E. Alouf,8 and Jean-Marc Cavaillon7,*

Département de Microbiologie des Ecosystèmes, Institut Pasteur de Lille,1 and Clinique des Maladies de l'Appareil Digestif. Hôpital Claude Huriez,6 Lille, INSERM U 395 CHU Purpan, Toulouse,5 and Department of Physiopathology7 and Unité des Toxines Microbiennes,8 Institut Pasteur, Paris, France; Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand2; and Department of Dermatology, University of Frankfurt, Frankfurt/Main,3 and Institute of Experimental Microbiology, Friedrich-Schiller University, Jena,4 Germany

Received 27 November 2000/Returned for modification 15 January 2001/Accepted 5 March 2001

Streptococcal mitogenic exotoxin Z (SMEZ), a superantigen derived from Streptococcus pyogenes, provoked expansion of human lymphocytes expressing the Vbeta 2, 4, 7 and 8 motifs of T-cell receptor. SMEZ was pyrogenic in rabbits and stimulated the expression of the T-cell activation markers CD69 and cutaneous lymphocyte-associated antigen. A variety of cytokines was released by human mononuclear leukocytes stimulated with SMEZ, which was 10-fold more active than streptococcal pyrogenic exotoxin A. Th2-derived cytokines were elicited only by superantigens and not by streptococcal cells.

* Corresponding author. Mailing address: Department of Physiopathology, Institut Pasteur, 28 rue Docteur Roux, 75015 Paris, France. Phone: 33 1 45 68 82 38. Fax: 33 1 40 61 31 60. E-mail: jmcavail{at}pasteur.fr.

Infection and Immunity, June 2001, p. 4141-4145, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4141-4145.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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