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Infection and Immunity, June 2001, p. 4168-4173, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4168-4173.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

gamma -Glutamyltransferase Is a Helicobacter pylori Virulence Factor but Is Not Essential for Colonization

K. J. McGovern,1 T. G. Blanchard,2,* J. A. Gutierrez,1 S. J. Czinn,2 S. Krakowka,3 and P. Youngman1

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts,1 and Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland,2 and Department of Veterinary Biosciences, Ohio State University, Columbus,3 Ohio

Received 28 November 2000/Returned for modification 12 January 2001/Accepted 8 March 2001

The contribution of glutamyl transpeptidase (GGT) (gamma -glutamyltransferase [EC 2. 3. 2. 2]) to Helicobacter pylori virulence was investigated in piglets and mice using GGT-deficient isogenic strains. All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization.

* Corresponding author. Mailing address: Division of Gastroenterology, Rainbow Babies & Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106. Phone: (216) 844-7363. Fax: (216) 844-7642. E-mail: tgb4{at}po.cwru.edu.

Infection and Immunity, June 2001, p. 4168-4173, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4168-4173.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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