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Infection and Immunity, June 2001, p. 4177-4179, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4177-4179.2001

Differential V T-Cell Receptor Usage during Chronic Experimental Schistosomiasis Corresponds with Distinct Pathological Presentations

W. Evan Secor^* and George L. Freeman Jr.

Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341-3724

Received 16 January 2001/Returned for modification 6 March 2001/Accepted 16 March 2001

CBA/J male mice with chronic Schistosoma mansoni infections display either moderate splenomegaly syndrome (MSS) or hypersplenomegaly syndrome (HSS). As MSS and HSS mice differ in several immunologic characteristics, we investigated T-cell receptor V usage. The groups had significantly different expression of several Vs, suggesting a relationship between the T-cell repertoire and schistosomiasis pathology.

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^* Corresponding author. Mailing address: Immunology Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Hwy., NE, MS-F13, Atlanta, GA 30341-3724. Phone: (770) 488-4115. Fax: (770) 488-3115. E-mail: was4{at}cdc.gov.

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Infection and Immunity, June 2001, p. 4177-4179, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4177-4179.2001