S-Fimbria-Encoding Determinant sfaI Is Located on Pathogenicity Island III536 of Uropathogenic Escherichia coli Strain 536

doi:10.1128/IAI.69.7.4248-4256.2001

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Infection and Immunity, July 2001, p. 4248-4256, Vol. 69, No. 7
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.7.4248-4256.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

S-Fimbria-Encoding Determinant sfa_I Is Located on Pathogenicity Island III₅₃₆ of Uropathogenic Escherichia coli Strain 536

Ulrich Dobrindt,¹ Gabriele Blum-Oehler,¹ Thomas Hartsch,² Gerhard Gottschalk,² Eliora Z. Ron,³ Reinhard Fünfstück,⁴ and Jörg Hacker¹^,^*

Institut für Molekulare Infektionsbiologie der Universität Würzburg, 97070 Würzburg,¹ Institut für Mikrobiologie und Genetik, Labor für Genomanalysen der Universität Göttingen, 37077 Göttingen,² and Klinik für Innere Medizin IV, Klinikum der Universität Jena, 07740 Jena,⁴ Germany, and Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Ramat Tel-Aviv, 69978 Tel Aviv, Israel³

Received 18 September 2000/Returned for modification 11 January 2001/Accepted 10 April 2001

The sfa_I determinant encoding the S-fimbrial adhesin of uropathogenic Escherichia coli strains was found to be located ona pathogenicity island of uropathogenic E. coli strain 536. Thispathogenicity island, designated PAI III₅₃₆, is located at 5.6min of the E. coli chromosome and covers a region of at least37 kb between the tRNA locus thrW and yagU. As far as it has beendetermined, PAI III₅₃₆ also contains genes which code for componentsof a putative enterochelin siderophore system of E. coli and Salmonellaspp. as well as for colicin V immunity. Several intact or nonfunctionalmobility genes of bacteriophages and insertion sequence elementssuch as transposases and integrases are present on PAI III₅₃₆.The presence of known PAI III₅₃₆ sequences has been investigatedin several wild-type E. coli isolates. The results demonstratethat the determinants of the members of the S-family of fimbrialadhesins may be located on a common pathogenicity island which,in E. coli strain 536, replaces a 40-kb DNA region which representsan E. coli K-12-specific genomicisland.

^* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Röntgenring 11, D-97070 Würzburg, Germany.Phone: 49 (0)931 312575. Fax: 49 (0)931 312578. E-mail: j.hacker{at}mail.uni-wuerzburg.de.

Infection and Immunity, July 2001, p. 4248-4256, Vol. 69, No. 7
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.7.4248-4256.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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