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Infection and Immunity, July 2001, p. 4248-4256, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4248-4256.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

S-Fimbria-Encoding Determinant sfaI Is Located on Pathogenicity Island III536 of Uropathogenic Escherichia coli Strain 536

Ulrich Dobrindt,1 Gabriele Blum-Oehler,1 Thomas Hartsch,2 Gerhard Gottschalk,2 Eliora Z. Ron,3 Reinhard Fünfstück,4 and Jörg Hacker1,*

Institut für Molekulare Infektionsbiologie der Universität Würzburg, 97070 Würzburg,1 Institut für Mikrobiologie und Genetik, Labor für Genomanalysen der Universität Göttingen, 37077 Göttingen,2 and Klinik für Innere Medizin IV, Klinikum der Universität Jena, 07740 Jena,4 Germany, and Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Ramat Tel-Aviv, 69978 Tel Aviv, Israel3

Received 18 September 2000/Returned for modification 11 January 2001/Accepted 10 April 2001

The sfaI determinant encoding the S-fimbrial adhesin of uropathogenic Escherichia coli strains was found to be located on a pathogenicity island of uropathogenic E. coli strain 536. This pathogenicity island, designated PAI III536, is located at 5.6 min of the E. coli chromosome and covers a region of at least 37 kb between the tRNA locus thrW and yagU. As far as it has been determined, PAI III536 also contains genes which code for components of a putative enterochelin siderophore system of E. coli and Salmonella spp. as well as for colicin V immunity. Several intact or nonfunctional mobility genes of bacteriophages and insertion sequence elements such as transposases and integrases are present on PAI III536. The presence of known PAI III536 sequences has been investigated in several wild-type E. coli isolates. The results demonstrate that the determinants of the members of the S-family of fimbrial adhesins may be located on a common pathogenicity island which, in E. coli strain 536, replaces a 40-kb DNA region which represents an E. coli K-12-specific genomic island.

* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Röntgenring 11, D-97070 Würzburg, Germany. Phone: 49 (0)931 312575. Fax: 49 (0)931 312578. E-mail: j.hacker{at}mail.uni-wuerzburg.de.

Infection and Immunity, July 2001, p. 4248-4256, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4248-4256.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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