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Infection and Immunity, July 2001, p. 4502-4508, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4502-4508.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Immune Response Induction and New Effector Mechanisms Possibly Involved in Protection Conferred by the Cuban Anti-Meningococcal BC Vaccine

Oliver Pérez,* Miriam Lastre, José Lapinet, Gustavo Bracho, Miriam Díaz, Caridad Zayas, Carlos Taboada, and Gustavo Sierra

Department of Basic and Clinical Immunology, Finlay Institute, Havana City, Cuba

Received 11 September 2000/Returned for modification 24 October 2000/Accepted 28 March 2001

This report explores the participation of some afferent mechanisms in the immune response induced by the Cuban anti-meningococcal vaccine VA-MENGOC-BC. The induction of delayed-type hypersensitivity in nursing babies and lymphocyte proliferation after immunization is demonstrated. The presence of gamma interferon IFN-gamma and interleukin-2 (IL-2) mRNAs but absence of IL-4, IL-5, and IL-10 mRNAs were observed in peripheral blood mononuclear cells from immunized subjects after in vitro challenge with outer membrane vesicles. In addition, some effector functions were also explored. The presence of opsonic activity was demonstrated in sera from vaccinees. The role of neutrophils as essential effector cells was shown. In conclusion, we have shown that, at least in the Cuban adult population, VA-MENGOC-BC induces mechanisms with a T-helper 1 pattern in the afferent and effector branches of the immune response.

* Corresponding author. Mailing address: Department of Basic and Clinical Immunology, Finlay Institute, P.O. Box 16017, Havana City, Cuba. Phone: 53 (7) 217597 or 53 (7) 218321. Fax: 53 (7) 286075. E-mail: oliverp{at}finlay.edu.cu.

Infection and Immunity, July 2001, p. 4502-4508, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4502-4508.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.