This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pannekoek, Y.
Right arrow Articles by Dankert, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pannekoek, Y.
Right arrow Articles by Dankert, J.

 Previous Article  |  Next Article 

Infection and Immunity, July 2001, p. 4654-4656, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4654-4656.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Normal IncA Expression and Fusogenicity of Inclusions in Chlamydia trachomatis Isolates with the incA I47T Mutation

Yvonne Pannekoek,1,* Arie van der Ende,1 Paul P. Eijk,1 Jan van Marle,2 Moniek A. de Witte,1 Jacobus M. Ossewaarde,3 Adriaan J. C. van den Brule,4 Servaas A. Morré,4 and Jacob Dankert1

Department of Medical Microbiology1 and Cell Biology and Histology, Section of Electron Microscopy,2 Academic Medical Center, University of Amsterdam, and Medical Center, Vrije Universiteit,4 Amsterdam, and Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven,3 The Netherlands

Received 20 December 2000/Returned for modification 14 March 2001/Accepted 26 March 2001

To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates were sequenced. Four major sequence types were identified. Seven isolates (28%) had the I47T mutation. Isolates representing the four sequence types expressed IncA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype.

* Corresponding author. Mailing address: Department of Medical Microbiology, Academic Medical Center, Room L1-162, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. Phone: 31 20 5664862. Fax: 31 20 6979271. E-mail: y.pannekoek{at}amc.uva.nl.

Infection and Immunity, July 2001, p. 4654-4656, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4654-4656.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Pannekoek, Y., Spaargaren, J., Langerak, A. A. J., Merks, J., Morre, S. A., van der Ende, A. (2005). Interrelationship between Polymorphisms of incA, Fusogenic Properties of Chlamydia trachomatis Strains, and Clinical Manifestations in Patients in The Netherlands. J. Clin. Microbiol. 43: 2441-2443 [Abstract] [Full Text]  
  • Rockey, D. D., Viratyosin, W., Bannantine, J. P., Suchland, R. J., Stamm, W. E. (2002). Diversity within inc genes of clinical Chlamydia trachomatis variant isolates that occupy non-fusogenic inclusions. Microbiology 148: 2497-2505 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»