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Infection and Immunity, July 2001, p. 4673-4677, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4673-4677.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro and In Vivo Assessment of Salmonella enterica Serovar Typhimurium DT104 Virulence

Chris A. Allen,1 Paula J. Fedorka-Cray,2 Andrés Vazquez-Torres,3 Mitsu Suyemoto,4 Craig Altier,4 L. Reeni Ryder,1 Ferric C. Fang,3 and Stephen J. Libby1,*

Department of Microbiology, North Carolina State University, Raleigh, North Carolina 276951; Poultry Microbiological Safety Research Unit, Richard B. Russell Agricultural Research Center, USDA Agricultural Research Services, Athens, Georgia 306042; Departments of Medicine and of Pathology and Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 802623; and Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 276064

Received 16 November 2000/Returned for modification 9 February 2001/Accepted 11 April 2001

Multidrug-resistant Salmonella enterica serovar Typhimurium phage type DT104 has become a widespread cause of human and other animal infection worldwide. The severity of clinical illness in S. enterica serovar Typhimurium DT104 outbreaks has led to the suggestion that this strain possesses enhanced virulence. In the present study, in vitro and in vivo virulence-associated phenotypes of several clinical isolates of S. enterica serovar Typhimurium DT104 were examined and compared to S. enterica serovar Typhimurium ATCC 14028s. The ability of these DT104 isolates to survive within murine peritoneal macrophages, invade cultured epithelial cells, resist antimicrobial actions of reactive oxygen and nitrogen compounds, and cause lethal infection in mice were assessed. Our results failed to demonstrate that S. enterica serovar Typhimurium DT104 isolates are more virulent than S. enterica serovar Typhimurium ATCC 14028s.

* Corresponding author. Mailing address: Department of Microbiology, Campus Box 7615, North Carolina State University, Raleigh, NC 27695-7615. Phone: (919) 513-1690. Fax: (919) 515-7867. E-mail: slibby{at}unity.ncsu.edu.

Infection and Immunity, July 2001, p. 4673-4677, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4673-4677.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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