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Infection and Immunity, July 2001, p. 4695-4697, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4695-4697.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Hyphae and Yeasts of Candida albicans Differentially Regulate Interleukin-12 Production by Human Blood Monocytes: Inhibitory Role of C. albicans Germination

Liming Liu,1,2 Kefei Kang,1,2,* Masakazu Takahara,2 Kevin D. Cooper,2,3 and Mahmoud A. Ghannoum1,2,3

The Center for Medical Mycology,1 Department of Dermatology,2 Case Western Reserve University and University Hospitals of Cleveland, and VA Medical Center,3 Cleveland, Ohio

Received 27 December 2000/Returned for modification 25 February 2001/Accepted 2 April 2001

The role of Candida albicans yeast-to-hypha transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.

* Corresponding author. Mailing address: Department of Dermatology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Ave. Rd., Cleveland, OH 44106. Phone: (216) 368-0234. Fax: (216) 368-0212. E-mail: kxk9{at}po.cwru.edu.

Infection and Immunity, July 2001, p. 4695-4697, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4695-4697.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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