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Infection and Immunity, August 2001, p. 5173-5176, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5173-5176.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Dendritic Cells Can Initiate Protective Immune Responses against Malaria

Oscar Bruña-Romero and Ana Rodriguez*

Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010

Received 26 October 2000/Returned for modification 13 December 2000/Accepted 2 May 2001

An understanding of the antigen presentation mechanisms that mediate induction of protective immune responses against malaria is essential for the development of successful immunization approaches. Here we show that dendritic cells presenting Plasmodium yoelii sporozoite antigens are able to activate specific CD4+ and CD8+ T cells and initiate protective immune responses against malaria in mice.

* Corresponding author. Mailing address: Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 E. 25th St., New York, NY 10010. USA Phone: (212) 263-6589. Fax: (212) 263-8116. E-mail: rodria02{at}popmail.med.nyu.edu.

Infection and Immunity, August 2001, p. 5173-5176, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5173-5176.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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