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Infection and Immunity, August 2001, p. 5177-5181, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5177-5181.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Coupled Phase-Variable Expression and Epitope Masking of Selective Surface Lipoproteins Increase Surface Phenotypic Diversity in Mycoplasma hominis

Qijing Zhangdagger and Kim S. Wise*

Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri 65212

Received 20 March 2001/Accepted 25 May 2001

A new mechanism expanding mycoplasmal surface diversity is described. Exposure of surface epitopes on a constitutively expressed membrane protein (P56) of Mycoplasma hominis was subject to high-frequency phase variation due to phase-variable expression of the P120 antigen and its selective masking of P56 epitopes. Phase-variable masking may confer previously unrealized adaptive capabilities on mycoplasmas.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212. Phone: (573) 882-8988. Fax: (573) 882-4287. E-mail: wisek{at}missouri.edu.

dagger Present address: Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH 44691.

Infection and Immunity, August 2001, p. 5177-5181, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5177-5181.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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