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Infection and Immunity, August 2001, p. 5189-5192, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5189-5192.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Interleukin-6 Deficiency Influences Cytokine Expression in Susceptible BALB Mice Infected with Leishmania major but Does Not Alter the Outcome of Disease

Richard G. Titus,^1,* Gregory K. DeKrey,² Robin V. Morris,¹ and Milena B. P. Soares³

Departments of Pathology¹ and Environmental Health,² College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523-1671, and Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil³

Received 19 March 2001/Returned for modification 12 April 2001/Accepted 2 May 2001

Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6^/) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6^/ and wild-type mice, but IL-6^/ mice expressed lower levels of Th2- and Th1-associated cytokines.

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^* Corresponding author. Mailing address: Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1671. Phone: (970) 491-4964. Fax: (970) 491-0603. E-mail: rtitus{at}cvmbs.colostate.edu.

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Infection and Immunity, August 2001, p. 5189-5192, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5189-5192.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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