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Infection and Immunity, August 2001, p. 5203-5206, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5203-5206.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Susceptibility of Mice to Vaginal Infection with Chlamydia trachomatis Mouse Pneumonitis Is Dependent on the Age of the Animal

Sukumar Pal, Ellena M. Peterson, and Luis M. de la Maza*

Department of Pathology, Medical Sciences, University of California, Irvine, Irvine, California 92697-4800

Received 28 November 2000/Returned for modification 5 March 2001/Accepted 11 May 2001

Mice from three strains, BALB/c (H-2d), C3H (H-2k), and C57BL/6 (H-2b), ranging from 5 to 14 weeks of age, were inoculated intravaginally with different doses of the Chlamydia trachomatis mouse pneumonitis serovar. Vaginal swabs taken at weekly intervals showed that the percentage of animals with positive cultures and the number of inclusion-forming units recovered per mouse were higher in the younger animals. Furthermore, vaginal shedding lasted longer in the young mice than in the older mice. In addition, following mating higher rates of infertility and a decrease in the number of embryos were observed in the infected young mice. In conclusion, susceptibility to a chlamydial vaginal infection is dependent on the age of the mice, with the older animals being more resistant.

* Corresponding author. Mailing address: Department of Pathology, Medical Sciences, Room D440, University of California, Irvine, Irvine, CA 92697-4800. Phone: (949) 824-7450. Fax: (949) 824-2160. E-mail: lmdelama{at}uci.edu.

Infection and Immunity, August 2001, p. 5203-5206, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5203-5206.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Maxion, H. K., Liu, W., Chang, M.-H., Kelly, K. A. (2004). The Infecting Dose of Chlamydia muridarum Modulates the Innate Immune Response and Ascending Infection. Infect. Immun. 72: 6330-6340 [Abstract] [Full Text]  
  • Pal, S., Peterson, E. M., de la Maza, L. M. (2004). New Murine Model for the Study of Chlamydia trachomatis Genitourinary Tract Infections in Males. Infect. Immun. 72: 4210-4216 [Abstract] [Full Text]  
  • Pal, S., Theodor, I., Peterson, E. M., de la Maza, L. M. (2001). Immunization with the Chlamydia trachomatis Mouse Pneumonitis Major Outer Membrane Protein Can Elicit a Protective Immune Response against a Genital Challenge. Infect. Immun. 69: 6240-6247 [Abstract] [Full Text]  


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