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Infection and Immunity, September 2001, p. 5931-5935, Vol. 69, No. 9
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.9.5931-5935.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Escherichia coli Cytotoxic Necrotizing Factor and Pasteurella multocida Toxin Induce Focal Adhesion Kinase Autophosphorylation and Src Association

Warren Thomas,1 Gillian D. Pullinger,1 Alistair J. Lax,1,* and Enrique Rozengurt2

Oral Microbiology Unit, King's College London, Guy's Hospital, London Bridge, London SE1 9RT, United Kingdom,1 and Department of Medicine, School of Medicine, and Molecular Biology Institute, University of California, Los Angeles, California 900952

Received 15 March 2001/Returned for modification 14 May 2001/Accepted 18 June 2001

Cytotoxic necrotizing factor 1 and Pasteurella multocida toxin induced dose- and time-dependent increases in focal adhesion kinase (FAK) Tyr397 phosphorylation in Swiss 3T3 cells. FAK autophosphorylation was sensitive to inhibitors of p160/ROCK and coincided with the formation of stable complexes between FAK and Src family members.

* Corresponding author. Mailing address: Oral Microbiology Unit, King's College London, Floor 28, Guy's Hospital, London Bridge, London SE1 9RT, United Kingdom. Phone: (44) 020 7955 2848. Fax: (44) 020 7955 2847. E-mail: alistair.lax{at}kcl.ac.uk.

Infection and Immunity, September 2001, p. 5931-5935, Vol. 69, No. 9
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.9.5931-5935.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Pullinger, G. D., Sowdhamini, R., Lax, A. J. (2001). Localization of Functional Domains of the Mitogenic Toxin of Pasteurella multocida. Infect. Immun. 69: 7839-7850 [Abstract] [Full Text]  
  • Thomas, W., Ascott, Z. K., Harmey, D., Slice, L. W., Rozengurt, E., Lax, A. J. (2001). Cytotoxic Necrotizing Factor from Escherichia coli Induces RhoA-Dependent Expression of the Cyclooxygenase-2 Gene. Infect. Immun. 69: 6839-6845 [Abstract] [Full Text]  


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