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Infection and Immunity, September 2001, p. 5949-5952, Vol. 69, No. 9
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.9.5949-5952.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Role of Endogenous Interleukin-12 in Immune Response to Staphylococcal Enterotoxin B in Mice

Fanny N. Lauw,1,2 Sandrine Florquin,3 Peter Speelman,2 Sander J. H. van Deventer,1 and Tom van der Poll1,2,*

Laboratory of Experimental Internal Medicine,1 Department of Infectious Diseases, Tropical Medicine and AIDS,2 and Department of Pathology,3 University of Amsterdam, Amsterdam, The Netherlands

Received 20 February 2001/Returned for modification 26 March 2001/Accepted 6 June 2001

In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.

* Corresponding author. Mailing address: Laboratory of Experimental Internal Medicine, Rm. G2-132, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5669111. Fax: 31-20-6977192. E-mail: T.vanderpoll{at}AMC.UVA.NL.

Infection and Immunity, September 2001, p. 5949-5952, Vol. 69, No. 9
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.9.5949-5952.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.