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Infect Immun. 1973 January; 7(1): 1-4
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Fluid Secretory Response of Bovine Thiry Jejunal Fistula to Enterotoxin of Clostridium perfringens

Animal Pathology Division, Health of Animals Branch, Canada Department of Agriculture, Animal Diseases Research Institute (Western), Lethbridge, Alberta, Canada TIJ 3Z4

ABSTRACT

The effect of enterotoxin of Clostridium perfringens type A was studied in Thiry fistula of the bovine jejunum. Accumulation of fluid as a pathological response was demonstrable within 30 min after introduction of enterotoxin into the fistula; the fluid volume increased rapidly within the first 2 hr and reached maximum in 7 hr. The enterotoxin was not destroyed by the jejunal fluid; 52% of it was absorbed in 2 to 3 hr, and all of the enterotoxin was taken up within 8 hr postinoculation. The accumulation of fluid by the fistula after 0.5 to 2 hr of exposure to enterotoxin ceased completely within 5 hr.