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Infect Immun. 1973 February; 7(2): 152-159
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Immunodepression by Rowson-Parr Virus in Mice. I. Growth Curves of Rowson-Parr Virus and Immunological Relationships with Friend Virus

M. Bendinelli and L. Nardini

Istituto di Microbiologia, Università di Pisa, Pisa, Italy

ABSTRACT

The growth curve of Rowson-Parr virus (RPV) was studied in the spleen of mice infected with RPV only and of mice infected with Friend virus (FV) preparations, which consist of a mixture of RPV and FV. In mice infected with FV preparations, RPV replicated to a higher titer than FV and attained higher levels than in singly infected mice. The chronic viremia of RPV-infected mice was found to coexist with circulating anti-RPV antibodies. These antibodies also neutralize FV and are probably responsible for the resistance against FV conferred to mice by prior infection with RPV.

Infect Immun. 1973 February; 7(2): 152-159
Copyright © 1973 American Society for Microbiology. All Rights Reserved.





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