This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Spencer, H. D. Articles by Cozad, G. C. Search for Related Content PubMed PubMed Citation Articles by Spencer, H. D. Articles by Cozad, G. C.

 Previous Article  |  Next Article 

Infect Immun. 1973 March; 7(3): 329-334
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Role of Delayed Hypersensitivity in Blastomycosis of Mice

^a Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73069

ABSTRACT

C57BL/6J mice rendered hypersensitive to Blastomyces dermatitidis were protected from the lethal effects of a blastomyces infection. This protection was observed following a lethal intraperitoneal challenge with viable cells 15 days after subcutaneous inoculation with 3.9 x 10⁴ viable cells. Delayed hypersensitivity was induced in C57 mice by two injections of Merthiolate-killed cells in adjuvant or by a single injection of viable cells. Development of hypersensitivity was determined at appropriate intervals by footpad injection with killed yeast cells.

¹ Present address: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Mich. 48104.

This article has been cited by other articles:

• Wuthrich, M., Finkel-Jiminez, B. E., Klein, B. S. (2000). Interleukin 12 as an Adjuvant to WI-1 Adhesin Immunization Augments Delayed-Type Hypersensitivity, Shifts the Subclass Distribution of Immunoglobulin G Antibodies, and Enhances Protective Immunity to Blastomyces dermatitidis Infection. Infect. Immun. 68: 7172-7174 [Abstract] [Full Text]  
• Wuthrich, M., Chang, W.-l., Klein, B. S. (1998). Immunogenicity and Protective Efficacy of the WI-1 Adhesin of Blastomyces dermatitidis. Infect. Immun. 66: 5443-5449 [Abstract] [Full Text]