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Infect Immun. 1973 March; 7(3): 352-355
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Transmissible Mink Encephalopathy: Studies on the Peripheral Lymphocyte

^a Department of Veterinary Science, University of Wisconsin, Madison, Wisconsin 53706

ABSTRACT

Circulating lymphocytes from mink with transmissible mink encephalopathy were studied for the presence of virus particles and for infectivity. Electron microscope examination of phytohemagglutinin-stimulated lymphocyte cultures revealed no evidence of virus-like particles. Circulating lymphocytes were also found to be noninfectious when the transmissible agent could be demonstrated in intact lymphoid organs in infected mink. A lymphopenia was detected in affected mink during the late clinical stage of disease, but this was most likely a secondary effect due to a terminal stress factor.

¹ Present address: National Animal Disease Laboratory, Ames, Iowa 50010.

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