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Infect Immun. 1973 March; 7(3): 361-365
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Protection Against Meningococcal Challenge Afforded Mice After Immunization with Typhoid-Paratyphoid Vaccine USP

^a Naval Medical Research Unit No. 4, Great Lakes, Illinois 60088

ABSTRACT

Mice immunized with typhoid-paratyphoid vaccine USP were found to be protected when challenged with serological groups A, B, and C of Neisseria meningitidis. Mice immunized with this vaccine both 14 and 7 days prior to challenge were protected against mean lethal doses (LD₅₀) of 5,220 and 1,151 of groups A and B, respectively, and in two separate experiments they were protected against 3,568 and 268 LD₅₀ of group C. Mice immunized four or more times on successive days prior to challenge were also protected. They demonstrated tolerance and survived a much larger LD₅₀ challenge than mice immunized by any other immunization schedule. Mice immunized once or twice anytime within 7 days prior to challenge were not protected and thus failed to exhibit nonspecific resistance. Serum antibody probably was responsible for the protection afforded mice immunized 14 and 7 days prior to challenge. However, this was not demonstrated conclusively.

¹ Present address: NAMRU-2, Taipei, Formosa, APO San Francisco 96263.

² Present address: U. S. Naval Station, FPO New York 09593.